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Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2.
Bugarcic A, Vetter I, Chalmers S, Kinna G, Collins BM, Teasdale RD. Bugarcic A, et al. Cell Biol Int. 2015 Nov;39(11):1299-306. doi: 10.1002/cbin.10508. Epub 2015 Jul 15. Cell Biol Int. 2015. PMID: 26113136
Retromer is a trimeric complex composed of Vps26, Vps29, and Vps35 and has been shown to be involved in trafficking and sorting of transmembrane proteins within the endosome. The Vps26 paralog, Vps26B, defines a distinct retromer complex (Vps26B-retromer) in vivo an …
Retromer is a trimeric complex composed of Vps26, Vps29, and Vps35 and has been shown to be involved in trafficking and sorting of transmemb …
Vps26A and Vps26B subunits define distinct retromer complexes.
Bugarcic A, Zhe Y, Kerr MC, Griffin J, Collins BM, Teasdale RD. Bugarcic A, et al. Traffic. 2011 Dec;12(12):1759-73. doi: 10.1111/j.1600-0854.2011.01284.x. Epub 2011 Oct 17. Traffic. 2011. PMID: 21920005 Free article.
Vps26B-retromer, like Vps26A-retromer, associates with TBC1D5 and GOLPH3. ...In summary, we show that the two distinct retromer complexes defined by different Vps26 paralogues are not functionally equivalent and that the Vps26B C-terminal region can control cargo se …
Vps26B-retromer, like Vps26A-retromer, associates with TBC1D5 and GOLPH3. ...In summary, we show that the two distinct retromer compl …
Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking.
Kim E, Lee Y, Lee HJ, Kim JS, Song BS, Huh JW, Lee SR, Kim SU, Kim SH, Hong Y, Shim I, Chang KT. Kim E, et al. Biochem Biophys Res Commun. 2010 Dec 10;403(2):167-71. doi: 10.1016/j.bbrc.2010.10.121. Epub 2010 Oct 30. Biochem Biophys Res Commun. 2010. PMID: 21040701
To elucidate the biological significance of the Vps26b isoform, we generated Vps26b knockout mice and studied their molecular, histological, and behavioral phenotypes. ...Vps26b-deficient mice showed a severe reduction of Vps35 protein at cellular level and l …
To elucidate the biological significance of the Vps26b isoform, we generated Vps26b knockout mice and studied their molecular, …
A novel mammalian retromer component, Vps26B.
Kerr MC, Bennetts JS, Simpson F, Thomas EC, Flegg C, Gleeson PA, Wicking C, Teasdale RD. Kerr MC, et al. Traffic. 2005 Nov;6(11):991-1001. doi: 10.1111/j.1600-0854.2005.00328.x. Traffic. 2005. PMID: 16190980 Free article.
Vps26B co-precipitated with Vps35 from transfected cells and the direct interaction between these two proteins was confirmed by yeast 2-hybrid analysis, thereby establishing Vps26B as a subunit of the retromer complex. ...Total internal reflection fluorescence micro …
Vps26B co-precipitated with Vps35 from transfected cells and the direct interaction between these two proteins was confirmed by yeast …
Structure of Vps26B and mapping of its interaction with the retromer protein complex.
Collins BM, Norwood SJ, Kerr MC, Mahony D, Seaman MN, Teasdale RD, Owen DJ. Collins BM, et al. Traffic. 2008 Mar;9(3):366-79. doi: 10.1111/j.1600-0854.2007.00688.x. Epub 2007 Dec 11. Traffic. 2008. PMID: 18088321 Free article.
The core of retromer is composed of three subunits vacuolar protein sorting (Vps)35, Vps26 and Vps29, and in mammals, there are two paralogues of the medium subunit Vps26A and Vps26B. We find that both Vps26A and Vps26B bind to Vps35/Vps29 with nanomolar affinity an …
The core of retromer is composed of three subunits vacuolar protein sorting (Vps)35, Vps26 and Vps29, and in mammals, there are two paralogu …
Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling.
Simoes S, Guo J, Buitrago L, Qureshi YH, Feng X, Kothiya M, Cortes E, Patel V, Kannan S, Kim YH, Chang KT; Alzheimer's Disease Neuroimaging Initiative; Hussaini SA, Moreno H, Di Paolo G, Andersen OM, Small SA. Simoes S, et al. Cell Rep. 2021 Dec 28;37(13):110182. doi: 10.1016/j.celrep.2021.110182. Cell Rep. 2021. PMID: 34965419 Free PMC article.
VPS26b was then found enriched in the trans-entorhinal cortex of human brains, where both VPS26b and the retromer-related receptor SORL1 were found deficient in AD. Finally, by regulating glutamate receptor and SORL1 recycling, we show that VPS26b can mediate …
VPS26b was then found enriched in the trans-entorhinal cortex of human brains, where both VPS26b and the retromer-related rece …
NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation.
Wang H, Qi W, Zou C, Xie Z, Zhang M, Naito MG, Mifflin L, Liu Z, Najafov A, Pan H, Shan B, Li Y, Zhu ZJ, Yuan J. Wang H, et al. Nat Commun. 2021 Aug 10;12(1):4826. doi: 10.1038/s41467-021-25157-7. Nat Commun. 2021. PMID: 34376696 Free PMC article.
Here we show that NEK1 regulates retromer-mediated endosomal trafficking by phosphorylating VPS26B. NEK1 deficiency disrupts endosomal trafficking of plasma membrane proteins and cerebral proteome homeostasis to promote mitochondrial and lysosomal dysfunction and aggregati …
Here we show that NEK1 regulates retromer-mediated endosomal trafficking by phosphorylating VPS26B. NEK1 deficiency disrupts endosoma …
Biogenesis of Rab14-positive endosome buds at Golgi-endosome contacts by the RhoBTB3-SHIP164-Vps26B complex.
Wang J, Xiong J, Zhang S, Li D, Chu Q, Chang W, Deng L, Ji WK. Wang J, et al. Cell Discov. 2024 Apr 2;10(1):38. doi: 10.1038/s41421-024-00651-6. Cell Discov. 2024. PMID: 38565878 Free PMC article.
In this study, we identify a protein complex comprising SHIP164, an ATPase RhoBTB3, and a retromer subunit Vps26B, which promotes the formation of EE buds at Golgi-EE contacts. Our findings reveal that Vps26B acts as a novel Rab14 effector, and Rab14 activity regula …
In this study, we identify a protein complex comprising SHIP164, an ATPase RhoBTB3, and a retromer subunit Vps26B, which promotes the …
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Xie S, Dierlam C, Smith E, Duran R, Williams A, Davis A, Mathew D, Naslavsky N, Iyer J, Caplan S. Xie S, et al. J Cell Sci. 2022 May 15;135(10):jcs259396. doi: 10.1242/jcs.259396. Epub 2022 May 17. J Cell Sci. 2022. PMID: 35510502 Free PMC article.
The mammalian retromer consists of subunits VPS26 (either VPS26A or VPS26B), VPS29 and VPS35, and a loosely associated sorting nexin (SNX) heterodimer or a variety of other SNX proteins. ...
The mammalian retromer consists of subunits VPS26 (either VPS26A or VPS26B), VPS29 and VPS35, and a loosely associated sorting nexin …
Pharmacologic enhancement of retromer rescues endosomal pathology induced by defects in the Alzheimer's gene SORL1.
Mishra S, Knupp A, Kinoshita C, Williams CA, Rose SE, Martinez R, Theofilas P, Young JE. Mishra S, et al. Stem Cell Reports. 2023 Dec 12;18(12):2434-2450. doi: 10.1016/j.stemcr.2023.10.011. Epub 2023 Nov 9. Stem Cell Reports. 2023. PMID: 37949073 Free PMC article.
We treated hiPSC-derived cortical neurons that are either fully deficient, haploinsufficient, or that harbor one copy of SORL1 variants linked to AD with TPT-260, a retromer-enhancing molecule. We show significant increases in retromer subunit VPS26B expression. We tested …
We treated hiPSC-derived cortical neurons that are either fully deficient, haploinsufficient, or that harbor one copy of SORL1 variants link …
22 results