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Year Number of Results
1994 2
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2001 1
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2003 4
2004 2
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2007 4
2008 2
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103 results

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Page 1
Mammalian VPS45 orchestrates trafficking through the endosomal system.
Frey L, Ziętara N, Łyszkiewicz M, Marquardt B, Mizoguchi Y, Linder MI, Liu Y, Giesert F, Wurst W, Dahlhoff M, Schneider MR, Wolf E, Somech R, Klein C. Frey L, et al. Blood. 2021 Apr 8;137(14):1932-1944. doi: 10.1182/blood.2020006871. Blood. 2021. PMID: 33512427 Free article.
Detailed mechanisms of the VPS45 function are unknown. Here, we show an essential role of mammalian VPS45 in maintaining the intracellular organization of endolysosomal vesicles and promoting recycling of cell-surface receptors. ...In this context, we demonstrate ab …
Detailed mechanisms of the VPS45 function are unknown. Here, we show an essential role of mammalian VPS45 in maintaining the i …
VPS45 is required for both diffuse and tip growth of Arabidopsis thaliana cells.
Mugume Y, Roy R, Agbemafle W, Shepard GN, Vue Y, Bassham DC. Mugume Y, et al. Front Plant Sci. 2023 Feb 27;14:1120307. doi: 10.3389/fpls.2023.1120307. eCollection 2023. Front Plant Sci. 2023. PMID: 36923123 Free PMC article.
It is also required for correct auxin distribution during gravitropism and lateral root growth. RESULTS: As vps45 knockout mutation is lethal in Arabidopsis, we identified a mutant, vps45-3, with a point mutation in the VPS45 gene causing a serine 284-to-phen …
It is also required for correct auxin distribution during gravitropism and lateral root growth. RESULTS: As vps45 knockout mutation i …
How we approach: Severe congenital neutropenia and myelofibrosis due to mutations in VPS45.
Shadur B, Asherie N, Newburger PE, Stepensky P. Shadur B, et al. Pediatr Blood Cancer. 2019 Jan;66(1):e27473. doi: 10.1002/pbc.27473. Epub 2018 Oct 7. Pediatr Blood Cancer. 2019. PMID: 30294941 Free PMC article. Review.
Mutations in the VPS45 gene lead to a severe primary immune deficiency characterized by severe congenital neutropenia and primary myelofibrosis, leading to overwhelming infection and early death. ...
Mutations in the VPS45 gene lead to a severe primary immune deficiency characterized by severe congenital neutropenia and primary mye …
The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation.
Eisemann TJ, Allen F, Lau K, Shimamura GR, Jeffrey PD, Hughson FM. Eisemann TJ, et al. Elife. 2020 Aug 17;9:e60724. doi: 10.7554/eLife.60724. Elife. 2020. PMID: 32804076 Free PMC article.
Here we present the structure of a second SM-Qa-SNARE complex, Vps45-Tlg2. Strikingly, Vps45 holds Tlg2 in an open conformation, with its SNARE motif disengaged from its Habc domain and its linker region unfolded. ...Although Tlg2 has a pronounced tendency to form h …
Here we present the structure of a second SM-Qa-SNARE complex, Vps45-Tlg2. Strikingly, Vps45 holds Tlg2 in an open conformatio …
A humanized Caenorhabditis elegans model for studying pathogenic mutations in VPS45, a protein essential for membrane trafficking, associated with severe congenital neutropenia.
Gengyo-Ando K, Tateyama M, Mitani S, Ando H, Nakai J. Gengyo-Ando K, et al. MicroPubl Biol. 2023 Nov 27;2023:10.17912/micropub.biology.001052. doi: 10.17912/micropub.biology.001052. eCollection 2023. MicroPubl Biol. 2023. PMID: 38089934 Free PMC article.
Here, we developed a humanized C. elegans model for three pathogenic VPS45 variants. We found that wild-type human VPS45 functionally complemented the loss of C. elegans VPS-45 , and the pathogenic human VPS45 variants functioned almost normally with respect …
Here, we developed a humanized C. elegans model for three pathogenic VPS45 variants. We found that wild-type human VPS45 funct …
A rare form of congenital neutropenia: VPS45 deficiency.
Karaatmaca B, Cagdas D, Tan Ç, Aytaç S, Özbek B, Üner A, Gümrük F, Tezcan İ. Karaatmaca B, et al. Scand J Immunol. 2020 May;91(5):e12871. doi: 10.1111/sji.12871. Epub 2020 Feb 27. Scand J Immunol. 2020. PMID: 32037586 Free article. No abstract available.
Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish.
Mochizuki T, Kojima Y, Nishiwaki Y, Harakuni T, Masai I. Mochizuki T, et al. Development. 2018 Oct 15;145(20):dev170282. doi: 10.1242/dev.170282. Development. 2018. PMID: 30322969 Free PMC article.
Here, we show that lens epithelial cells abnormally enter lens fiber differentiation without passing through the equator in zebrafish vps45 mutants. VPS45 belongs to the Sec1/Munc18-like protein family and promotes endosome trafficking, which differentially modulate …
Here, we show that lens epithelial cells abnormally enter lens fiber differentiation without passing through the equator in zebrafish vps …
Periodontal Disease in Two Siblings with VPS45-associated Severe Congenital Neutropenia Type V: A Case Report.
Alotaibi FA, Albarkheel AI. Alotaibi FA, et al. Int J Clin Pediatr Dent. 2020 Sep-Oct;13(5):572-575. doi: 10.5005/jp-journals-10005-1841. Int J Clin Pediatr Dent. 2020. PMID: 33623350 Free PMC article.
VPS45-associated severe congenital neutropenia type V (VPS45-associated SCN5) is an autosomal recessive disorder caused by defective endosomal intracellular protein trafficking due to mutations in VPS45 underlies a reduced absolute neutrophil count >500 ce …
VPS45-associated severe congenital neutropenia type V (VPS45-associated SCN5) is an autosomal recessive disorder caused by def …
Early Endosomal Trafficking Component BEN2/VPS45 Plays a Crucial Role in Internal Tissues in Regulating Root Growth and Meristem Size in Arabidopsis.
Matsuura Y, Fukasawa N, Ogita K, Sasabe M, Kakimoto T, Tanaka H. Matsuura Y, et al. Front Plant Sci. 2020 Jul 9;11:1027. doi: 10.3389/fpls.2020.01027. eCollection 2020. Front Plant Sci. 2020. PMID: 32754181 Free PMC article.
Furthermore, BEN2/VPS45 rescued the root architecture defects when expressed in internal tissues of ben1; ben2 double mutants. These results corroborate the roles of the endosomal trafficking component BEN2/VPS45 in regulation of auxin-dependent developmental proces …
Furthermore, BEN2/VPS45 rescued the root architecture defects when expressed in internal tissues of ben1; ben2 double mutants. These …
103 results