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218 results

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Page 1
Identification of Evolutionarily Conserved VSX2 Enhancers in Retinal Development.
Honnell V, Sweeney S, Norrie J, Ramirez C, Xu B, Teubner B, Lee AY, Bell C, Dyer MA. Honnell V, et al. bioRxiv [Preprint]. 2023 Oct 17:2023.10.17.562742. doi: 10.1101/2023.10.17.562742. bioRxiv. 2023. PMID: 37905144 Free PMC article. Preprint.
Recently, we found that distinct modules within a murine SE regulate gene expression of master regulatory transcription factor Vsx2 in a developmental stage- and cell-type specific manner. Vsx2 is expressed in retinal progenitor cells as well as differentiated bipol …
Recently, we found that distinct modules within a murine SE regulate gene expression of master regulatory transcription factor Vsx2 i …
VSX2 mutations in autosomal recessive microphthalmia.
Reis LM, Khan A, Kariminejad A, Ebadi F, Tyler RC, Semina EV. Reis LM, et al. Mol Vis. 2011;17:2527-32. Epub 2011 Sep 28. Mol Vis. 2011. PMID: 21976963 Free PMC article.
METHODS: We screened 95 probands with syndromic or isolated developmental ocular conditions (including 55 with anophthalmia/microphthalmia) for mutations in VSX2. RESULTS: Homozygous mutations in VSX2 were identified in two out of five consanguineous families with i …
METHODS: We screened 95 probands with syndromic or isolated developmental ocular conditions (including 55 with anophthalmia/microphthalmia) …
Vsx2 in the zebrafish retina: restricted lineages through derepression.
Vitorino M, Jusuf PR, Maurus D, Kimura Y, Higashijima S, Harris WA. Vitorino M, et al. Neural Dev. 2009 Apr 3;4:14. doi: 10.1186/1749-8104-4-14. Neural Dev. 2009. PMID: 19344499 Free PMC article.
The Vsx2-negative daughters of Vsx2-positive RPCs divide and give rise to all other cell types in the retina. ...Foxn4, expressed in the progenitors of amacrine and horizontal cells, is also negatively regulated by Vsx2. CONCLUSION: Our data thus suggest V …
The Vsx2-negative daughters of Vsx2-positive RPCs divide and give rise to all other cell types in the retina. ...Foxn4, expres …
VSX2 and ASCL1 Are Indicators of Neurogenic Competence in Human Retinal Progenitor Cultures.
Wright LS, Pinilla I, Saha J, Clermont JM, Lien JS, Borys KD, Capowski EE, Phillips MJ, Gamm DM. Wright LS, et al. PLoS One. 2015 Aug 20;10(8):e0135830. doi: 10.1371/journal.pone.0135830. eCollection 2015. PLoS One. 2015. PMID: 26292211 Free PMC article.
Short term prenatal 3D retinal cultures displayed multiple characteristics of human RPCs (hRPCs) found in situ, including robust expression of VSX2. Upon initiation of hRPC differentiation, there was a small increase in co-labeling of VSX2+ cells with ASCL1, along w …
Short term prenatal 3D retinal cultures displayed multiple characteristics of human RPCs (hRPCs) found in situ, including robust expression …
Functional analysis of the Vsx2 super-enhancer uncovers distinct cis-regulatory circuits controlling Vsx2 expression during retinogenesis.
Bian F, Daghsni M, Lu F, Liu S, Gross JM, Aldiri I. Bian F, et al. Development. 2022 Aug 1;149(15):dev200642. doi: 10.1242/dev.200642. Epub 2022 Aug 8. Development. 2022. PMID: 35831950 Free PMC article.
Here, we have profiled VSX2 genomic occupancy during mouse retinogenesis, revealing extensive retinal genetic programs associated with VSX2 during development. VSX2 binds and transactivates its enhancer in association with the transcription factor PAX6. ...
Here, we have profiled VSX2 genomic occupancy during mouse retinogenesis, revealing extensive retinal genetic programs associated wit …
Simultaneous deletion of Prdm1 and Vsx2 enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes.
Goodson NB, Kaufman MA, Park KU, Brzezinski JA 4th. Goodson NB, et al. Development. 2020 Jul 3;147(13):dev190272. doi: 10.1242/dev.190272. Development. 2020. PMID: 32541005 Free PMC article.
The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. PRDM1 and VSX2 work in opposition, such that PRDM1 promotes pho …
The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcriptio …
Mutations in VSX2, SOX2, and FOXE3 Identified in Patients with Micro-/Anophthalmia.
Habibi I, Youssef M, Marzouk E, El Shakankiri N, Gawdat G, El Sada M, F Schorderet D, Abou Zeid H. Habibi I, et al. Adv Exp Med Biol. 2019;1185:221-226. doi: 10.1007/978-3-030-27378-1_36. Adv Exp Med Biol. 2019. PMID: 31884615
A new homozygous frameshift mutation c.[422delA];[422delA], p.[N141Ifs19];[N141Ifs19] in VSX2 was identified in a patient showing bilateral anophthalmia. ...
A new homozygous frameshift mutation c.[422delA];[422delA], p.[N141Ifs19];[N141Ifs19] in VSX2 was identified in a patient showing bil …
Association of Missense Variants in VSX2 With a Peculiar Form of Congenital Stationary Night Blindness Affecting All Bipolar Cells.
Smirnov VM, Robert MP, Condroyer C, Navarro J, Antonio A, Rozet JM, Sahel JA, Perrault I, Audo I, Zeitz C. Smirnov VM, et al. JAMA Ophthalmol. 2022 Dec 1;140(12):1163-1173. doi: 10.1001/jamaophthalmol.2022.4146. JAMA Ophthalmol. 2022. PMID: 36264558 Free PMC article.
Exome sequencing and co-segregation analysis in a consanguineous family with 2 affected members identified a homozygous variant in VSX2. Subsequently, screening of the CSNB cohort identified another unrelated patient harboring a distinct VSX2 variant. CONCLUSIONS AN …
Exome sequencing and co-segregation analysis in a consanguineous family with 2 affected members identified a homozygous variant in VSX2 …
Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells.
Sigulinsky CL, German ML, Leung AM, Clark AM, Yun S, Levine EM. Sigulinsky CL, et al. Neural Dev. 2015 Apr 27;10:12. doi: 10.1186/s13064-015-0039-5. Neural Dev. 2015. PMID: 25927996 Free PMC article.
However, our understanding of the mechanisms by which Vsx2 does this is still rudimentary. To define the autonomy requirements for Vsx2 in the regulation of RPC properties, we generated chimeric mouse embryos comprised of wild-type and Vsx2-deficient cells. . …
However, our understanding of the mechanisms by which Vsx2 does this is still rudimentary. To define the autonomy requirements for …
Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells.
Capowski EE, Wright LS, Liang K, Phillips MJ, Wallace K, Petelinsek A, Hagstrom A, Pinilla I, Borys K, Lien J, Min JH, Keles S, Thomson JA, Gamm DM. Capowski EE, et al. Stem Cells. 2016 Nov;34(11):2625-2634. doi: 10.1002/stem.2414. Epub 2016 Jul 5. Stem Cells. 2016. PMID: 27301076 Free PMC article.
Few gene targets of Visual System Homeobox 2 (VSX2) have been identified despite its broad and critical role in the maintenance of neural retina (NR) fate during early retinogenesis. We performed VSX2 ChIP-seq and ChIP-PCR assays on early stage optic vesicle-like st …
Few gene targets of Visual System Homeobox 2 (VSX2) have been identified despite its broad and critical role in the maintenance of ne …
218 results