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beta-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells.
Ji C, Zhao H, Chen D, Zhang H, Zhao YG. Ji C, et al. Curr Biol. 2021 Apr 26;31(8):1666-1677.e6. doi: 10.1016/j.cub.2021.01.081. Epub 2021 Feb 25. Curr Biol. 2021. PMID: 33636118 Free article.
BPAN- and ID-related mutations of WDR45/45B fail to rescue the autophagy defects in Wdr45/45b-deficient cells, possibly due to their impaired binding to EPG5. Promoting autophagosome maturation by inhibiting O-GlcNAcylation increases SNARE complex formation and faci …
BPAN- and ID-related mutations of WDR45/45B fail to rescue the autophagy defects in Wdr45/45b-deficient cells, possibly due to …
Cross-cancer profiling of molecular alterations within the human autophagy interaction network.
Lebovitz CB, Robertson AG, Goya R, Jones SJ, Morin RD, Marra MA, Gorski SM. Lebovitz CB, et al. Autophagy. 2015;11(9):1668-87. doi: 10.1080/15548627.2015.1067362. Autophagy. 2015. PMID: 26208877 Free PMC article.
Aberrant activation or disruption of autophagy promotes tumorigenesis in various preclinical models of cancer, but whether the autophagy pathway is a target for recurrent molecular alteration in human cancer patient samples is unknown. ...Gene expression analyses re …
Aberrant activation or disruption of autophagy promotes tumorigenesis in various preclinical models of cancer, but whether the autoph …
TRAPPC11 functions in autophagy by recruiting ATG2B-WIPI4/WDR45 to preautophagosomal membranes.
Stanga D, Zhao Q, Milev MP, Saint-Dic D, Jimenez-Mallebrera C, Sacher M. Stanga D, et al. Traffic. 2019 May;20(5):325-345. doi: 10.1111/tra.12640. Epub 2019 Apr 9. Traffic. 2019. PMID: 30843302 Free article.
A proximity biotinylation assay identified ATG2B and its binding partner WIPI4/WDR45 as TRAPPC11 interactors. TRAPPC11 depletion phenocopies that of ATG2 and WIPI4 and recruitment of both proteins to membranes is defective upon reduction of TRAPPC11. ...
A proximity biotinylation assay identified ATG2B and its binding partner WIPI4/WDR45 as TRAPPC11 interactors. TRAPPC11 depletion phen …
Sex differences in autophagy-mediated diseases: toward precision medicine.
Shang D, Wang L, Klionsky DJ, Cheng H, Zhou R. Shang D, et al. Autophagy. 2021 May;17(5):1065-1076. doi: 10.1080/15548627.2020.1752511. Epub 2020 Apr 17. Autophagy. 2021. PMID: 32264724 Free PMC article. Review.
Accumulating evidence shows that macroautophagy/autophagy, as a mechanism for development, differentiation, survival, and homeostasis, is involved in numerous aspects of sex differences in diseases such as cancer, neurodegeneration, and cardiovascular diseases. Advances in …
Accumulating evidence shows that macroautophagy/autophagy, as a mechanism for development, differentiation, survival, and homeostasis, is in …
Identification of an 11-Autophagy-Related-Gene Signature as Promising Prognostic Biomarker for Bladder Cancer Patients.
Zhou C, Li AH, Liu S, Sun H. Zhou C, et al. Biology (Basel). 2021 Apr 27;10(5):375. doi: 10.3390/biology10050375. Biology (Basel). 2021. PMID: 33925460 Free PMC article.
BACKGROUND: Survival rates for highly invasive bladder cancer (BC) patients have been very low, with a 5-year survival rate of 6%. ...RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1 …
BACKGROUND: Survival rates for highly invasive bladder cancer (BC) patients have been very low, with a 5-year survival rate of 6%. .. …
A gene toolbox for monitoring autophagy transcription.
Bordi M, De Cegli R, Testa B, Nixon RA, Ballabio A, Cecconi F. Bordi M, et al. Cell Death Dis. 2021 Nov 2;12(11):1044. doi: 10.1038/s41419-021-04121-9. Cell Death Dis. 2021. PMID: 34728604 Free PMC article.
Moreover, we have curated two shorter sub-lists to predict the extent of autophagy activation and/or lysosomal biogenesis; we next validated the "induction list" by Real-time PCR in cell lines during fasting or MTOR inhibition, identifying ATG14, ATG7, NBR1, ULK1, ULK2, and WD …
Moreover, we have curated two shorter sub-lists to predict the extent of autophagy activation and/or lysosomal biogenesis; we next validated …
Functional Linkage of RKIP to the Epithelial to Mesenchymal Transition and Autophagy during the Development of Prostate Cancer.
Ahmed M, Lai TH, Zada S, Hwang JS, Pham TM, Yun M, Kim DR. Ahmed M, et al. Cancers (Basel). 2018 Aug 16;10(8):273. doi: 10.3390/cancers10080273. Cancers (Basel). 2018. PMID: 30115852 Free PMC article.
In particular, the loss of RKIP's function in certain types of cancer cells results in epithelial to mesenchymal transition (EMT) and the promotion of cancer metastasis. ...How the RKIP-dependent inhibition of autophagy is linked to EMT and cancer progression …
In particular, the loss of RKIP's function in certain types of cancer cells results in epithelial to mesenchymal transition (EMT) and …
A Novel Autophagy-Related Prognostic Risk Model and a Nomogram for Survival Prediction of Oral Cancer Patients.
Fei H, Chen X. Fei H, et al. Biomed Res Int. 2022 Jan 6;2022:2067540. doi: 10.1155/2022/2067540. eCollection 2022. Biomed Res Int. 2022. PMID: 35036428 Free PMC article.
Univariate and multivariate Cox regression analyses were adopted for searching prognostic ARGs, and an autophagy-associated signature for ORCA patients was constructed. Eventually, 4 desirable independent survival-related ARGs (WDR45, MAPK9, VEGFA, and ATIC) were confirmed …
Univariate and multivariate Cox regression analyses were adopted for searching prognostic ARGs, and an autophagy-associated signature for OR …
Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis.
Bai M, Che Y, Lu K, Fu L. Bai M, et al. PeerJ. 2020 Jun 30;8:e9146. doi: 10.7717/peerj.9146. eCollection 2020. PeerJ. 2020. PMID: 32655987 Free PMC article.
However, little is known about its function in tumors. Cervical cancer is a malignant tumor that seriously endangers the lives of women. ...We demonstrated that OTUD5 affects the expression levels of WD repeat domain 45 (WDR45), ubiquitin-specific peptidase 11 (USP1 …
However, little is known about its function in tumors. Cervical cancer is a malignant tumor that seriously endangers the lives of wom …
Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration.
Yamada M, Maeta K, Suzuki H, Kurosawa R, Takenouchi T, Awaya T, Ajiro M, Takeuchi A, Nishio H, Hagiwara M, Miya F, Matsuo M, Kosaki K. Yamada M, et al. Sci Rep. 2024 Mar 18;14(1):6506. doi: 10.1038/s41598-024-56704-z. Sci Rep. 2024. PMID: 38499569 Free PMC article.
Pathogenic variants in WDR45 on chromosome Xp11 cause neurodegenerative disorder beta-propeller protein-associated neurodegeneration (BPAN). ...Whole genome sequencing and RNA sequencing revealed generation of pseudoexon due to inclusion of intronic sequences triggered by …
Pathogenic variants in WDR45 on chromosome Xp11 cause neurodegenerative disorder beta-propeller protein-associated neurodegeneration …
14 results