Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2014 1
2019 1
2020 2
2021 2
2022 2
2023 3
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

12 results

Results by year

Filters applied: . Clear all
Page 1
WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/beta-catenin signaling pathway.
Cai Z, Mei Y, Jiang X, Shi X. Cai Z, et al. Open Life Sci. 2021 Sep 6;16(1):920-929. doi: 10.1515/biol-2021-0096. eCollection 2021. Open Life Sci. 2021. PMID: 34553072 Free PMC article.
Colon cancer (CRC) is a common type of cancer and has a high incidence worldwide. ...In summary, WDR74 could be a potential target for the intervention of CRC....
Colon cancer (CRC) is a common type of cancer and has a high incidence worldwide. ...In summary, WDR74 could be a poten …
WDR74 induces nuclear beta-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis.
Li Y, Chen F, Shen W, Li B, Xiang R, Qu L, Zhang C, Li G, Xie H, Katanaev VL, Jia L. Li Y, et al. Cancer Lett. 2020 Feb 28;471:103-115. doi: 10.1016/j.canlet.2019.12.011. Epub 2019 Dec 12. Cancer Lett. 2020. PMID: 31838084
Herein, WDR74 expression was observed to be increased upon lung cancer progression from healthy normal tissues to the primary cancer and further to the metastatic cancer. ...WDR74 can serve as a candidate target for the prevention and treatment …
Herein, WDR74 expression was observed to be increased upon lung cancer progression from healthy normal tissues to the primary …
A Pan-Cancer Analysis of the Oncogenic Role of WD Repeat Domain 74 in Multiple Tumors.
Wu X, Song P, Wang S, Qian Z, Ying J, Gao S, Li W. Wu X, et al. Front Genet. 2022 Apr 26;13:860940. doi: 10.3389/fgene.2022.860940. eCollection 2022. Front Genet. 2022. PMID: 35559034 Free PMC article.
WDR74 is highly expressed in most cancers and correlated with poor prognosis in several cancers (all p < 0.05). ...Our first pan-cancer study inferred a relatively comprehensive understanding of the oncogenic roles of WDR74 across various …
WDR74 is highly expressed in most cancers and correlated with poor prognosis in several cancers (all p < 0.05). ...O …
WDR74 rs11231247 contributes to the susceptibility and prognosis of non-small cell lung cancer.
Wu F, Wu H, Hu W, Zhang Z, Zhang X. Wu F, et al. Pathol Res Pract. 2023 Feb;242:154318. doi: 10.1016/j.prp.2023.154318. Epub 2023 Jan 21. Pathol Res Pract. 2023. PMID: 36701849
OBJECTIVES: WD repeat-containing protein 74 (WDR74) has been linked with the development of lung cancer. This study aims to investigate the relationship between WDR74 rs11231247 and non-small cell lung cancer (NSCLC) susceptibility and the prognosis of …
OBJECTIVES: WD repeat-containing protein 74 (WDR74) has been linked with the development of lung cancer. This study aims to in …
WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5-MDM2-p53 pathway.
Li Y, Zhou Y, Li B, Chen F, Shen W, Lu Y, Zhong C, Zhang C, Xie H, Katanaev VL, Jia L. Li Y, et al. Oncogene. 2020 Mar;39(13):2741-2755. doi: 10.1038/s41388-020-1179-6. Epub 2020 Jan 31. Oncogene. 2020. PMID: 32005977
Moreover, WDR74 contributed to melanoma growth and metastasis in vivo. Mechanistically, WDR74 modulates RPL5 protein levels and consequently regulates MDM2 and insulates the ubiquitination degradation of p53 by MDM2. Our study is the first to reveal the oncogenic ro …
Moreover, WDR74 contributed to melanoma growth and metastasis in vivo. Mechanistically, WDR74 modulates RPL5 protein levels an …
WDR74 serves as a novel therapeutic target by its oncogenic role in hepatocellular carcinoma.
Gao F, Zhou H, Huang X, Xie H, Zhou L, Chen J, Zheng S. Gao F, et al. Pathol Res Pract. 2023 Aug;248:154622. doi: 10.1016/j.prp.2023.154622. Epub 2023 Jun 14. Pathol Res Pract. 2023. PMID: 37331183
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most refractory human malignancies. WD repeat-containing protein 74 (WDR74) is involved in the tumorigenesis of various cancers, however, its clinical implications and biological function in HCC have yet to be …
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most refractory human malignancies. WD repeat-containing protein 74 (WDR74) …
Properties of non-coding mutation hotspots as urinary biomarkers for bladder cancer detection.
Baxter L, Gordon NS, Ott S, Wang J, Patel P, Goel A, Piechocki K, Silcock L, Sale C, Zeegers MP, Cheng KK, James ND; BladderPath trial management group; Bryan RT, Ward DG. Baxter L, et al. Sci Rep. 2023 Jan 19;13(1):1060. doi: 10.1038/s41598-023-27675-4. Sci Rep. 2023. PMID: 36658180 Free PMC article.
Mutations at specific hotspots in non-coding regions of ADGRG6, PLEKHS1, WDR74, TBC1D12 and LEPROTL1 frequently occur in bladder cancer (BC). ...
Mutations at specific hotspots in non-coding regions of ADGRG6, PLEKHS1, WDR74, TBC1D12 and LEPROTL1 frequently occur in bladder c …
Genome-wide analysis of noncoding regulatory mutations in cancer.
Weinhold N, Jacobsen A, Schultz N, Sander C, Lee W. Weinhold N, et al. Nat Genet. 2014 Nov;46(11):1160-5. doi: 10.1038/ng.3101. Epub 2014 Sep 28. Nat Genet. 2014. PMID: 25261935 Free PMC article.
Cancer primarily develops because of somatic alterations in the genome. ...Here we analyze the complete genome sequences of 863 human tumors from The Cancer Genome Atlas and other sources to systematically identify noncoding regions that are recurrently mutated in …
Cancer primarily develops because of somatic alterations in the genome. ...Here we analyze the complete genome sequences of 863 human …
Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations.
Hao BB, Ma K, Xu JY, Fan RF, Zhao WS, Jia XL, Zhai LH, Lee S, Xie D, Tan MJ. Hao BB, et al. Acta Pharmacol Sin. 2024 Jun;45(6):1305-1315. doi: 10.1038/s41401-024-01236-5. Epub 2024 Feb 21. Acta Pharmacol Sin. 2024. PMID: 38383757
Histone deacetylase inhibitors (HDACis) are important drugs for cancer therapy, but the indistinct resistant mechanisms of solid tumor therapy greatly limit their clinical application. In this study we conducted HDACi-perturbated proteomics and phosphoproteomics analyses i …
Histone deacetylase inhibitors (HDACis) are important drugs for cancer therapy, but the indistinct resistant mechanisms of solid tumo …
Identification of genetic mutations related to invasion and metastasis of acral melanoma via whole-exome sequencing.
Lim Y, Lee DY. Lim Y, et al. J Dermatol. 2021 Jul;48(7):999-1006. doi: 10.1111/1346-8138.15841. Epub 2021 Apr 23. J Dermatol. 2021. PMID: 33890690
SDM present only in the metastatic lesion were ANO1, CPEB1, EP300, INADL, MAP1B, MAP7D1, MARCH6, NETO1, PRKCE, SBK1, TNRC6A, USP13, WDR74, and ZNF827. In conclusion, we applied multi-region WES to investigate possible pathogenic mutations related to invasion and metastasis …
SDM present only in the metastatic lesion were ANO1, CPEB1, EP300, INADL, MAP1B, MAP7D1, MARCH6, NETO1, PRKCE, SBK1, TNRC6A, USP13, WDR74 …
12 results