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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 1
2010 4
2011 12
2012 11
2013 8
2014 21
2015 59
2016 48
2017 51
2018 72
2019 77
2020 98
2021 73
2022 43
2023 33
2024 23

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559 results

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Page 1
YAP/TAZ at the Roots of Cancer.
Zanconato F, Cordenonsi M, Piccolo S. Zanconato F, et al. Cancer Cell. 2016 Jun 13;29(6):783-803. doi: 10.1016/j.ccell.2016.05.005. Cancer Cell. 2016. PMID: 27300434 Free PMC article. Review.
Recent work indicates that, remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cell attributes, proliferation, chemoresistance, and metastasis. ...Addiction to YAP/TAZ thus potentially represe …
Recent work indicates that, remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation …
YAP and WWTR1: New targets for skin cancer treatment.
Andl T, Zhou L, Yang K, Kadekaro AL, Zhang Y. Andl T, et al. Cancer Lett. 2017 Jun 28;396:30-41. doi: 10.1016/j.canlet.2017.03.001. Epub 2017 Mar 7. Cancer Lett. 2017. PMID: 28279717 Review.
The core components of the Hippo signaling pathway are a cascade of kinases that govern the phosphorylation of downstream transcriptional co-activators, namely, YES-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TA …
The core components of the Hippo signaling pathway are a cascade of kinases that govern the phosphorylation of downstream transcriptional co …
Role of YAP/TAZ in mechanotransduction.
Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N, Piccolo S. Dupont S, et al. Nature. 2011 Jun 8;474(7350):179-83. doi: 10.1038/nature10137. Nature. 2011. PMID: 21654799
By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behaviour, including growth, differentiation and cancer malignant progression, but how rigidity mechanosensing is ultimately linked to activity of nu …
By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behaviour, inclu …
Insights into recent findings and clinical application of YAP and TAZ in cancer.
Franklin JM, Wu Z, Guan KL. Franklin JM, et al. Nat Rev Cancer. 2023 Aug;23(8):512-525. doi: 10.1038/s41568-023-00579-1. Epub 2023 Jun 12. Nat Rev Cancer. 2023. PMID: 37308716 Review.
The paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), as the central transcription control module of the Hippo pathway, have long been implicated in the progression of various human cancers. The current literature regard …
The paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), as the central transcription cont …
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.
Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, Ahmad M, Dimaras H, Langille E, Cole SPC, Monnier PP, Lok BH, Tsao MS, Akeno N, Schramek D, Wikenheiser-Brokamp KA, Knudsen ES, Witkiewicz AK, Wrana JL, Goodrich DW, Bremner R. Pearson JD, et al. Cancer Cell. 2021 Aug 9;39(8):1115-1134.e12. doi: 10.1016/j.ccell.2021.06.016. Epub 2021 Jul 21. Cancer Cell. 2021. PMID: 34270926 Free PMC article.
YAP(off) solid cancers are neural/neuroendocrine and frequently RB1(-/-), such as retinoblastoma, small cell lung cancer, and neuroendocrine prostate cancer. ...Mechanistically, distinct YAP/TEAD enhancers in YAP(off) or YAP(on) cancers deploy anti- …
YAP(off) solid cancers are neural/neuroendocrine and frequently RB1(-/-), such as retinoblastoma, small cell lung cancer, and …
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. Zhang Z, et al. Mol Cell. 2019 Jan 3;73(1):7-21.e7. doi: 10.1016/j.molcel.2018.10.030. Epub 2018 Nov 21. Mol Cell. 2019. PMID: 30472188 Free article.
It is yet unknown why the YAP/ TAZ proteins are frequently activated in human malignancies in which the Hippo pathway is still active. Here, by a gain-of-function cancer metastasis screen, we discovered OTUB2 as a cancer stemness and metastasis-promoting factor that …
It is yet unknown why the YAP/ TAZ proteins are frequently activated in human malignancies in which the Hippo pathway is still active. Here, …
YAP/TAZ upstream signals and downstream responses.
Totaro A, Panciera T, Piccolo S. Totaro A, et al. Nat Cell Biol. 2018 Aug;20(8):888-899. doi: 10.1038/s41556-018-0142-z. Epub 2018 Jul 26. Nat Cell Biol. 2018. PMID: 30050119 Free PMC article. Review.
Corruption of cell-environment interplay leads to aberrant YAP and TAZ activation that is instrumental for multiple diseases, including cancer....
Corruption of cell-environment interplay leads to aberrant YAP and TAZ activation that is instrumental for multiple diseases, including c …
A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer.
Yang WH, Huang Z, Wu J, Ding CC, Murphy SK, Chi JT. Yang WH, et al. Mol Cancer Res. 2020 Jan;18(1):79-90. doi: 10.1158/1541-7786.MCR-19-0691. Epub 2019 Oct 22. Mol Cancer Res. 2020. PMID: 31641008 Free PMC article.
Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. ...Collectively, cell density-regulated ferroptosis in ovarian cancer is mediated by TAZ through the regula …
Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating nove …
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Lin S, Choe J, Du P, Triboulet R, Gregory RI. Lin S, et al. Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21. Mol Cell. 2016. PMID: 27117702 Free PMC article.
Here we find that METTL3 promotes translation of certain mRNAs including epidermal growth factor receptor (EGFR) and the Hippo pathway effector TAZ in human cancer cells. In contrast to current models that invoke m(6)A reader proteins downstream of nuclear METTL3, we find …
Here we find that METTL3 promotes translation of certain mRNAs including epidermal growth factor receptor (EGFR) and the Hippo pathway effec …
559 results