Wagner A - Search Results

1

Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.

Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA. Wagner A, et al. Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3640-3644. doi: 10.1002/anie.201810470. Epub 2019 Jan 30. Angew Chem Int Ed Engl. 2019. PMID: 30605929

2

Backbone NMR assignments of tryparedoxin, the central protein in the hydroperoxide detoxification cascade of African trypanosomes, in the oxidized and reduced form.

Wagner A, Diehl E, Krauth-Siegel RL, Hellmich UA. Wagner A, et al. Biomol NMR Assign. 2017 Oct;11(2):193-196. doi: 10.1007/s12104-017-9746-7. Epub 2017 Jun 1. Biomol NMR Assign. 2017. PMID: 28573456

3

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M. Previti S, et al. Among authors: wagner a. J Med Chem. 2017 Aug 24;60(16):6911-6923. doi: 10.1021/acs.jmedchem.7b00405. Epub 2017 Aug 11. J Med Chem. 2017. PMID: 28763614

4

Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.

Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA. Viet KK, et al. Among authors: wagner a. Structure. 2019 Aug 6;27(8):1246-1257.e5. doi: 10.1016/j.str.2019.04.016. Epub 2019 Jun 6. Structure. 2019. PMID: 31178222 Free article.

5

Cis autocatalytic cleavage of glycine-linked Zika virus NS2B-NS3 protease constructs.

von Hammerstein F, Lauth LM, Hammerschmidt S, Wagner A, Schirmeister T, Hellmich UA. von Hammerstein F, et al. Among authors: wagner a. FEBS Lett. 2019 Aug;593(16):2204-2213. doi: 10.1002/1873-3468.13507. Epub 2019 Jul 9. FEBS Lett. 2019. PMID: 31240714 Free article.

6

Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis.

Ettari R, Previti S, Maiorana S, Amendola G, Wagner A, Cosconati S, Schirmeister T, Hellmich UA, Zappalà M. Ettari R, et al. Among authors: wagner a. J Med Chem. 2019 Dec 12;62(23):10617-10629. doi: 10.1021/acs.jmedchem.9b00908. Epub 2019 Nov 27. J Med Chem. 2019. PMID: 31714776

7

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain.

Klein P, Johe P, Wagner A, Jung S, Kühlborn J, Barthels F, Tenzer S, Distler U, Waigel W, Engels B, Hellmich UA, Opatz T, Schirmeister T. Klein P, et al. Among authors: wagner a. Molecules. 2020 Mar 23;25(6):1451. doi: 10.3390/molecules25061451. Molecules. 2020. PMID: 32210166 Free PMC article.

8

Predicting ¹⁹ F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase-Inhibitor Complex.

Dietschreit JCB, Wagner A, Le TA, Klein P, Schindelin H, Opatz T, Engels B, Hellmich UA, Ochsenfeld C. Dietschreit JCB, et al. Among authors: wagner a. Angew Chem Int Ed Engl. 2020 Jul 27;59(31):12669-12673. doi: 10.1002/anie.202000539. Epub 2020 May 25. Angew Chem Int Ed Engl. 2020. PMID: 32239740 Free PMC article.

9

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics.

Klein P, Barthels F, Johe P, Wagner A, Tenzer S, Distler U, Le TA, Schmid P, Engel V, Engels B, Hellmich UA, Opatz T, Schirmeister T. Klein P, et al. Among authors: wagner a. Molecules. 2020 Apr 28;25(9):2064. doi: 10.3390/molecules25092064. Molecules. 2020. PMID: 32354191 Free PMC article.

10

Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment.

Maiorana S, Ettari R, Previti S, Amendola G, Wagner A, Cosconati S, Hellmich UA, Schirmeister T, Zappalà M. Maiorana S, et al. Among authors: wagner a. ChemMedChem. 2020 Aug 19;15(16):1552-1561. doi: 10.1002/cmdc.202000360. Epub 2020 Jul 7. ChemMedChem. 2020. PMID: 32567172

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