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NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.
Hiraike Y, Waki H, Yu J, Nakamura M, Miyake K, Nagano G, Nakaki R, Suzuki K, Kobayashi H, Yamamoto S, Sun W, Aoyama T, Hirota Y, Ohno H, Oki K, Yoneda M, White AP, Tseng YH, Cypess AM, Larsen TJ, Jespersen NZ, Scheele C, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T. Hiraike Y, et al. Among authors: waki h. Nat Cell Biol. 2017 Sep;19(9):1081-1092. doi: 10.1038/ncb3590. Epub 2017 Aug 14. Nat Cell Biol. 2017. PMID: 28812581 Free PMC article.
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. Yamauchi T, et al. Among authors: waki h. Nat Med. 2001 Aug;7(8):941-6. doi: 10.1038/90984. Nat Med. 2001. PMID: 11479627
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance.
Yamauchi T, Kamon J, Waki H, Murakami K, Motojima K, Komeda K, Ide T, Kubota N, Terauchi Y, Tobe K, Miki H, Tsuchida A, Akanuma Y, Nagai R, Kimura S, Kadowaki T. Yamauchi T, et al. Among authors: waki h. J Biol Chem. 2001 Nov 2;276(44):41245-54. doi: 10.1074/jbc.M103241200. Epub 2001 Aug 31. J Biol Chem. 2001. PMID: 11533050 Free article.
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
Yamauchi T, Waki H, Kamon J, Murakami K, Motojima K, Komeda K, Miki H, Kubota N, Terauchi Y, Tsuchida A, Tsuboyama-Kasaoka N, Yamauchi N, Ide T, Hori W, Kato S, Fukayama M, Akanuma Y, Ezaki O, Itai A, Nagai R, Kimura S, Tobe K, Kagechika H, Shudo K, Kadowaki T. Yamauchi T, et al. Among authors: waki h. J Clin Invest. 2001 Oct;108(7):1001-13. doi: 10.1172/JCI12864. J Clin Invest. 2001. PMID: 11581301 Free PMC article.
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice.
Yamauchi T, Oike Y, Kamon J, Waki H, Komeda K, Tsuchida A, Date Y, Li MX, Miki H, Akanuma Y, Nagai R, Kimura S, Saheki T, Nakazato M, Naitoh T, Yamamura K, Kadowaki T. Yamauchi T, et al. Among authors: waki h. Nat Genet. 2002 Feb;30(2):221-6. doi: 10.1038/ng829. Epub 2002 Jan 30. Nat Genet. 2002. PMID: 11818964
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.
Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T. Yamauchi T, et al. Among authors: waki h. J Biol Chem. 2003 Jan 24;278(4):2461-8. doi: 10.1074/jbc.M209033200. Epub 2002 Nov 12. J Biol Chem. 2003. PMID: 12431986 Free article.
214 results