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The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.
Ji Y, Walkowicz MJ, Buiting K, Johnson DK, Tarvin RE, Rinchik EM, Horsthemke B, Stubbs L, Nicholls RD. Ji Y, et al. Among authors: walkowicz mj. Hum Mol Genet. 1999 Mar;8(3):533-42. doi: 10.1093/hmg/8.3.533. Hum Mol Genet. 1999. PMID: 9949213