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The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.
Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Wang D, Qiu JX, Zhou SF. Li JP, et al. Among authors: wang d. Drug Des Devel Ther. 2015 Mar 16;9:1627-52. doi: 10.2147/DDDT.S75378. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25834401 Free PMC article.
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.
Ren T, Shan J, Qing Y, Qian C, Li Q, Lu G, Li M, Li C, Peng Y, Luo H, Zhang S, Zhang W, Wang D, Zhou SF. Ren T, et al. Among authors: wang d. Drug Des Devel Ther. 2014 Dec 12;8:2517-29. doi: 10.2147/DDDT.S71432. eCollection 2014. Drug Des Devel Ther. 2014. PMID: 25548514 Free PMC article.
Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang YX, Zhang X, Duan W, Yang T, Qiu JX, Zhou SF. Ding YH, et al. Among authors: wang d. Drug Des Devel Ther. 2015 Jan 9;9:425-64. doi: 10.2147/DDDT.S74062. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25624750 Free PMC article.
Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells.
Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF. Wang F, et al. Among authors: wang d, wang q. Drug Des Devel Ther. 2015 Jan 17;9:537-60. doi: 10.2147/DDDT.S73689. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25632222 Free PMC article.
Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach.
Pan ST, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF. Pan ST, et al. Among authors: wang d. Drug Des Devel Ther. 2015 Feb 17;9:937-68. doi: 10.2147/DDDT.S76021. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25733813 Free PMC article.
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