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Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Zhong Z, et al. Among authors: wang y. J Neurosci. 2010 Nov 17;30(46):15521-34. doi: 10.1523/JNEUROSCI.4437-10.2010. J Neurosci. 2010. PMID: 21084607 Free PMC article.
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A.
Nikolakopoulou AM, Wang Y, Ma Q, Sagare AP, Montagne A, Huuskonen MT, Rege SV, Kisler K, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic BV. Nikolakopoulou AM, et al. Among authors: wang y. J Exp Med. 2021 Apr 5;218(4):e20202207. doi: 10.1084/jem.20202207. J Exp Med. 2021. PMID: 33533918 Free PMC article.
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