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Platelet GPVI repairs its own damage.
Rayes J, Watson SP. Rayes J, et al. Among authors: watson sp. Blood. 2015 Aug 20;126(8):933-4. doi: 10.1182/blood-2015-06-650838. Blood. 2015. PMID: 26294718 Free article.
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.
Hitchcock JR, Cook CN, Bobat S, Ross EA, Flores-Langarica A, Lowe KL, Khan M, Dominguez-Medina CC, Lax S, Carvalho-Gaspar M, Hubscher S, Rainger GE, Cobbold M, Buckley CD, Mitchell TJ, Mitchell A, Jones ND, Van Rooijen N, Kirchhofer D, Henderson IR, Adams DH, Watson SP, Cunningham AF. Hitchcock JR, et al. Among authors: watson sp. J Clin Invest. 2015 Dec;125(12):4429-46. doi: 10.1172/JCI79070. Epub 2015 Nov 16. J Clin Invest. 2015. PMID: 26571395 Free PMC article.
Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.
Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP. Lax S, et al. Among authors: watson sp. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1016-L1029. doi: 10.1152/ajplung.00023.2017. Epub 2017 Aug 24. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28839100 Free PMC article.
The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.
Rayes J, Lax S, Wichaiyo S, Watson SK, Di Y, Lombard S, Grygielska B, Smith SW, Skordilis K, Watson SP. Rayes J, et al. Among authors: watson sk, watson sp. Nat Commun. 2017 Dec 21;8(1):2239. doi: 10.1038/s41467-017-02402-6. Nat Commun. 2017. PMID: 29269852 Free PMC article.
The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.
Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B. Rayes J, et al. Among authors: watson sp. Haematologica. 2018 Jun;103(6):e256-e258. doi: 10.3324/haematol.2017.182162. Epub 2018 Feb 1. Haematologica. 2018. PMID: 29419432 Free PMC article. No abstract available.
Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps.
Beristain-Covarrubias N, Perez-Toledo M, Flores-Langarica A, Zuidscherwoude M, Hitchcock JR, Channell WM, King LDW, Thomas MR, Henderson IR, Rayes J, Watson SP, Cunningham AF. Beristain-Covarrubias N, et al. Among authors: watson sp. Blood. 2019 Feb 7;133(6):600-604. doi: 10.1182/blood-2018-08-867267. Epub 2018 Nov 6. Blood. 2019. PMID: 30401709 Free PMC article.
488 results