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Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Murphy JM, et al. Among authors: wei l. J Med Chem. 2013 Sep 12;56(17):6696-708. doi: 10.1021/jm400457y. Epub 2013 Aug 15. J Med Chem. 2013. PMID: 23947754 Free PMC article.
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Nathanson DA, et al. Among authors: wei l. J Exp Med. 2014 Mar 10;211(3):473-86. doi: 10.1084/jem.20131738. Epub 2014 Feb 24. J Exp Med. 2014. PMID: 24567448 Free PMC article.
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, Taechariyakul T, Yaghoubi SS, Lee JT, Sadeghi S, Lavie A, Faull KF, Witte ON, Donahue TR, Phelps ME, Herschman HR, Herrmann K, Czernin J, Radu CG. Kim W, et al. Among authors: wei l. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4027-32. doi: 10.1073/pnas.1524212113. Epub 2016 Mar 28. Proc Natl Acad Sci U S A. 2016. PMID: 27035974 Free PMC article.
Evaluation of the Genisys4, a bench-top preclinical PET scanner.
Herrmann K, Dahlbom M, Nathanson D, Wei L, Radu C, Chatziioannou A, Czernin J. Herrmann K, et al. Among authors: wei l. J Nucl Med. 2013 Jul;54(7):1162-7. doi: 10.2967/jnumed.112.114926. Epub 2013 Apr 29. J Nucl Med. 2013. PMID: 23628700 Free PMC article.
Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Abt ER, Rosser EW, Durst MA, Lok V, Poddar S, Le TM, Cho A, Kim W, Wei L, Song J, Capri JR, Xu S, Wu N, Slavik R, Jung ME, Damoiseaux R, Czernin J, Donahue TR, Lavie A, Radu CG. Abt ER, et al. Among authors: wei l. Cell Chem Biol. 2020 Feb 20;27(2):197-205.e6. doi: 10.1016/j.chembiol.2019.10.012. Epub 2019 Nov 13. Cell Chem Biol. 2020. PMID: 31734178 Free PMC article.
Development and preclinical pharmacology of a novel dCK inhibitor, DI-87.
Poddar S, Capparelli EV, Rosser EW, Gipson RM, Wei L, Le T, Jung ME, Radu C, Nikanjam M. Poddar S, et al. Among authors: wei l. Biochem Pharmacol. 2020 Feb;172:113742. doi: 10.1016/j.bcp.2019.113742. Epub 2019 Dec 6. Biochem Pharmacol. 2020. PMID: 31812677 Free PMC article.
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.
Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG. Le TM, et al. Among authors: wei l. Nat Commun. 2017 Aug 14;8(1):241. doi: 10.1038/s41467-017-00221-3. Nat Commun. 2017. PMID: 28808226 Free PMC article.
STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [18F]FLT PET imaging.
Liang K, Abt ER, Le TM, Cho A, Dann AM, Cui J, Li L, Rashid K, Creech AL, Wei L, Ghukasyan R, Rosser EW, Wu N, Carlucci G, Czernin J, Donahue TR, Radu CG. Liang K, et al. Among authors: wei l. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105390118. doi: 10.1073/pnas.2105390118. Proc Natl Acad Sci U S A. 2021. PMID: 34480004 Free PMC article.
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