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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. Inuzuka H, et al. Among authors: wei w. Nature. 2011 Mar 3;471(7336):104-9. doi: 10.1038/nature09732. Nature. 2011. PMID: 21368833 Free PMC article.
Acetylation-dependent regulation of Skp2 function.
Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Inuzuka H, et al. Among authors: wei w. Cell. 2012 Jul 6;150(1):179-93. doi: 10.1016/j.cell.2012.05.038. Cell. 2012. PMID: 22770219 Free PMC article.
The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W. Shimizu K, et al. Among authors: wei w. Sci Signal. 2017 Jan 3;10(460):eaah4117. doi: 10.1126/scisignal.aah4117. Sci Signal. 2017. PMID: 28049764 Free PMC article.
NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.
Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H. Fukushima H, et al. Among authors: wei w. Mol Cell. 2017 Nov 16;68(4):645-658.e5. doi: 10.1016/j.molcel.2017.10.018. Mol Cell. 2017. PMID: 29149593 Free PMC article.
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