Wells G - Search Results

1

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.

Bertrand HC, Schaap M, Baird L, Georgakopoulos ND, Fowkes A, Thiollier C, Kachi H, Dinkova-Kostova AT, Wells G. Bertrand HC, et al. Among authors: wells g. J Med Chem. 2015 Sep 24;58(18):7186-94. doi: 10.1021/acs.jmedchem.5b00602. J Med Chem. 2015. PMID: 26348784

2

Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.

Berry JM, Bradshaw TD, Fichtner I, Ren R, Schwalbe CH, Wells G, Chew EH, Stevens MF, Westwell AD. Berry JM, et al. Among authors: wells g. J Med Chem. 2005 Jan 27;48(2):639-44. doi: 10.1021/jm040859h. J Med Chem. 2005. PMID: 15658878

3

Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines.

Mortimer CG, Wells G, Crochard JP, Stone EL, Bradshaw TD, Stevens MF, Westwell AD. Mortimer CG, et al. Among authors: wells g. J Med Chem. 2006 Jan 12;49(1):179-85. doi: 10.1021/jm050942k. J Med Chem. 2006. PMID: 16392802

4

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE. Wells G, et al. J Med Chem. 2006 Sep 7;49(18):5442-61. doi: 10.1021/jm051199z. J Med Chem. 2006. PMID: 16942018

5

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.

Wells G, Suggitt M, Coffils M, Baig MA, Howard PW, Loadman PM, Hartley JA, Jenkins TC, Thurston DE. Wells G, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2147-51. doi: 10.1016/j.bmcl.2008.01.083. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18280154

6

Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box.

Brucoli F, Hawkins RM, James CH, Wells G, Jenkins TC, Ellis T, Hartley JA, Howard PW, Thurston DE. Brucoli F, et al. Among authors: wells g. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3780-3. doi: 10.1016/j.bmcl.2011.04.054. Epub 2011 Apr 20. Bioorg Med Chem Lett. 2011. PMID: 21570842

7

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction.

Hancock R, Bertrand HC, Tsujita T, Naz S, El-Bakry A, Laoruchupong J, Hayes JD, Wells G. Hancock R, et al. Among authors: wells g. Free Radic Biol Med. 2012 Jan 15;52(2):444-51. doi: 10.1016/j.freeradbiomed.2011.10.486. Epub 2011 Nov 3. Free Radic Biol Med. 2012. PMID: 22107959

8

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity.

Hancock R, Schaap M, Pfister H, Wells G. Hancock R, et al. Among authors: wells g. Org Biomol Chem. 2013 Jun 7;11(21):3553-7. doi: 10.1039/c3ob40249e. Epub 2013 Apr 24. Org Biomol Chem. 2013. PMID: 23615671

9

Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction.

Schaap M, Hancock R, Wilderspin A, Wells G. Schaap M, et al. Among authors: wells g. Protein Sci. 2013 Dec;22(12):1812-9. doi: 10.1002/pro.2384. Protein Sci. 2013. PMID: 24130096 Free PMC article.

10

3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.

Nagle AA, Reddy SA, Bertrand H, Tajima H, Dang TM, Wong SC, Hayes JD, Wells G, Chew EH. Nagle AA, et al. Among authors: wells g. ChemMedChem. 2014 Aug;9(8):1763-74. doi: 10.1002/cmdc.201402038. Epub 2014 May 12. ChemMedChem. 2014. PMID: 24819554

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