Wen X - Search Results

1

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. Bosanac I, et al. Among authors: wen x. Nat Struct Mol Biol. 2009 Jul;16(7):691-7. doi: 10.1038/nsmb.1632. Epub 2009 Jun 28. Nat Struct Mol Biol. 2009. PMID: 19561609

2

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates.

Austin CD, Wen X, Gazzard L, Nelson C, Scheller RH, Scales SJ. Austin CD, et al. Among authors: wen x. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17987-92. doi: 10.1073/pnas.0509035102. Epub 2005 Dec 1. Proc Natl Acad Sci U S A. 2005. PMID: 16322102 Free PMC article.

3

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS. Endoh-Yamagami S, et al. Among authors: wen x. Curr Biol. 2009 Aug 11;19(15):1320-6. doi: 10.1016/j.cub.2009.06.046. Epub 2009 Jul 9. Curr Biol. 2009. PMID: 19592253 Free article.

4

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.

Wen X, Lai CK, Evangelista M, Hongo JA, de Sauvage FJ, Scales SJ. Wen X, et al. Mol Cell Biol. 2010 Apr;30(8):1910-22. doi: 10.1128/MCB.01089-09. Epub 2010 Feb 12. Mol Cell Biol. 2010. PMID: 20154143 Free PMC article.

5

Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.

Maun HR, Wen X, Lingel A, de Sauvage FJ, Lazarus RA, Scales SJ, Hymowitz SG. Maun HR, et al. Among authors: wen x. J Biol Chem. 2010 Aug 20;285(34):26570-80. doi: 10.1074/jbc.M110.112284. Epub 2010 May 26. J Biol Chem. 2010. PMID: 20504762 Free PMC article.

6

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK. Mukhopadhyay S, et al. Among authors: wen x. Genes Dev. 2010 Oct 1;24(19):2180-93. doi: 10.1101/gad.1966210. Genes Dev. 2010. PMID: 20889716 Free PMC article.

7

Functional characterization of putative cilia genes by high-content analysis.

Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ. Lai CK, et al. Among authors: wen x. Mol Biol Cell. 2011 Apr;22(7):1104-19. doi: 10.1091/mbc.E10-07-0596. Epub 2011 Feb 2. Mol Biol Cell. 2011. PMID: 21289087 Free PMC article.

8

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK. Sang L, et al. Among authors: wen x. Cell. 2011 May 13;145(4):513-28. doi: 10.1016/j.cell.2011.04.019. Cell. 2011. PMID: 21565611 Free PMC article.

9

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK. Mukhopadhyay S, et al. Among authors: wen x. Cell. 2013 Jan 17;152(1-2):210-23. doi: 10.1016/j.cell.2012.12.026. Cell. 2013. PMID: 23332756 Free article.

10

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R. Osterwalder M, et al. Among authors: wen x. Dev Cell. 2014 Nov 10;31(3):345-357. doi: 10.1016/j.devcel.2014.09.018. Epub 2014 Nov 10. Dev Cell. 2014. PMID: 25453830 Free PMC article.

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