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Showing results for wendy loop
Your search for Wendy Loope retrieved no results
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, Graves AP, Fairweather E, Werner T, Raoof A, Butlin RJ, Rueda L, Horton JR, Fosbenner DT, Zhang C, Handler JL, Muliaditan M, Mebrahtu M, Jaworski JP, McNulty DE, Burt C, Eberl HC, Taylor AN, Ho T, Merrihew S, Foley SW, Rutkowska A, Li M, Romeril SP, Goldberg K, Zhang X, Kershaw CS, Bantscheff M, Jurewicz AJ, Minthorn E, Grandi P, Patel M, Benowitz AB, Mohammad HP, Gilmartin AG, Prinjha RK, Ogilvie D, Carpenter C, Heerding D, Baylin SB, Jones PA, Cheng X, King BW, Luengo JI, Jordan AM, Waddell I, Kruger RG, McCabe MT. Pappalardi MB, et al. Nat Cancer. 2021 Oct;2(10):1002-1017. Epub 2021 Sep 27. Nat Cancer. 2021. PMID: 34790902 Free PMC article.
Herein we report the discovery of GSK3685032, a potent first-in-class DNMT1-selective inhibitor that was shown via crystallographic studies to compete with the active-site loop of DNMT1 for penetration into hemi-methylated DNA between two CpG base pairs. ...
Herein we report the discovery of GSK3685032, a potent first-in-class DNMT1-selective inhibitor that was shown via crystallographic studies …
TADs do not stay in the loop.
Michieletto D, Bickmore WA. Michieletto D, et al. Mol Cell. 2022 Jun 16;82(12):2188-2189. doi: 10.1016/j.molcel.2022.05.033. Mol Cell. 2022. PMID: 35714583 Free article.
Ultra-long-range interactions between active regulatory elements.
Friman ET, Flyamer IM, Marenduzzo D, Boyle S, Bickmore WA. Friman ET, et al. Genome Res. 2023 Aug;33(8):1269-1283. doi: 10.1101/gr.277567.122. Epub 2023 Jul 14. Genome Res. 2023. PMID: 37451823 Free PMC article.
We propose that long-range interactions between cis-regulatory elements are driven by at least three distinct processes: cohesin-mediated loop extrusion, polycomb contacts, and clustering of active regions....
We propose that long-range interactions between cis-regulatory elements are driven by at least three distinct processes: cohesin-mediated …
Cohesin is required for long-range enhancer action at the Shh locus.
Kane L, Williamson I, Flyamer IM, Kumar Y, Hill RE, Lettice LA, Bickmore WA. Kane L, et al. Nat Struct Mol Biol. 2022 Sep;29(9):891-897. doi: 10.1038/s41594-022-00821-8. Epub 2022 Sep 12. Nat Struct Mol Biol. 2022. PMID: 36097291 Free PMC article.
It has been suggested that three-dimensional genome organization, particularly topologically associating domains formed by cohesin-mediated loop extrusion, is important for enhancers to act over such large genomic distances. ...Our findings support the hypothesis that chro …
It has been suggested that three-dimensional genome organization, particularly topologically associating domains formed by cohesin-mediated …
A new model of cuprizone-mediated demyelination/remyelination.
Sachs HH, Bercury KK, Popescu DC, Narayanan SP, Macklin WB. Sachs HH, et al. ASN Neuro. 2014 Sep 30;6(5):1759091414551955. doi: 10.1177/1759091414551955. Print 2014. ASN Neuro. 2014. PMID: 25290063 Free PMC article.
Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development.
Dai J, Bercury KK, Jin W, Macklin WB. Dai J, et al. J Neurosci. 2015 Dec 2;35(48):15875-93. doi: 10.1523/JNEUROSCI.0882-15.2015. J Neurosci. 2015. PMID: 26631469 Free PMC article.
We identified three functional nuclear export sequences (NES) localized in the basic helix-loop-helix domain and one specific acetylation site at Lys 150 (human Olig1) in NES1. ...
We identified three functional nuclear export sequences (NES) localized in the basic helix-loop-helix domain and one specific acetyla …
Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI).
Aung MT, M Bakulski K, Feinberg JI, F Dou J, D Meeker J, Mukherjee B, Loch-Caruso R, Ladd-Acosta C, Volk HE, Croen LA, Hertz-Picciotto I, Newschaffer CJ, Fallin MD. Aung MT, et al. Epigenetics. 2022 Mar;17(3):253-268. doi: 10.1080/15592294.2021.1897059. Epub 2021 Apr 2. Epigenetics. 2022. PMID: 33794742 Free PMC article.
Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity.
Williamson I, Lettice LA, Hill RE, Bickmore WA. Williamson I, et al. Development. 2016 Aug 15;143(16):2994-3001. doi: 10.1242/dev.139188. Epub 2016 Jul 11. Development. 2016. PMID: 27402708 Free PMC article.
Conventional and super-resolution light microscopy identified significantly elevated frequencies of Shh/ZRS colocalisation only in the Shh-expressing regions of the limb bud, in a conformation consistent with enhancer-promoter loop formation. However, in all tissues and at …
Conventional and super-resolution light microscopy identified significantly elevated frequencies of Shh/ZRS colocalisation only in the Shh-e …
Differences in Glycoprotein Complex Receptor Binding Site Accessibility Prompt Poor Cross-Reactivity of Neutralizing Antibodies between Closely Related Arenaviruses.
Brouillette RB, Phillips EK, Ayithan N, Maury W. Brouillette RB, et al. J Virol. 2017 Mar 13;91(7):e01454-16. doi: 10.1128/JVI.01454-16. Print 2017 Apr 1. J Virol. 2017. PMID: 28100617 Free PMC article.
However, these MAbs were unable to bind to a chimeric GPC composed of JUNV GP1 containing a small disulfide bonded loop (loop 10) unique to MACV GPC, suggesting that this loop may block MAbs interaction with the GP1 RBS. Consistent with this loop causi …
However, these MAbs were unable to bind to a chimeric GPC composed of JUNV GP1 containing a small disulfide bonded loop (loop …
13 results