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Activity-based probes for the multicatalytic proteasome.
Hewings DS, Flygare JA, Wertz IE, Bogyo M. Hewings DS, et al. Among authors: wertz ie. FEBS J. 2017 May;284(10):1540-1554. doi: 10.1111/febs.14016. Epub 2017 Feb 7. FEBS J. 2017. PMID: 28107776 Free article. Review.
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.
Hewings DS, Heideker J, Ma TP, AhYoung AP, El Oualid F, Amore A, Costakes GT, Kirchhofer D, Brasher B, Pillow T, Popovych N, Maurer T, Schwerdtfeger C, Forrest WF, Yu K, Flygare J, Bogyo M, Wertz IE. Hewings DS, et al. Among authors: wertz ie. Nat Commun. 2018 Mar 21;9(1):1162. doi: 10.1038/s41467-018-03511-6. Nat Commun. 2018. PMID: 29563501 Free PMC article.
Targeted degradation via direct 26S proteasome recruitment.
Bashore C, Prakash S, Johnson MC, Conrad RJ, Kekessie IA, Scales SJ, Ishisoko N, Kleinheinz T, Liu PS, Popovych N, Wecksler AT, Zhou L, Tam C, Zilberleyb I, Srinivasan R, Blake RA, Song A, Staben ST, Zhang Y, Arnott D, Fairbrother WJ, Foster SA, Wertz IE, Ciferri C, Dueber EC. Bashore C, et al. Among authors: wertz ie. Nat Chem Biol. 2023 Jan;19(1):55-63. doi: 10.1038/s41589-022-01218-w. Epub 2022 Dec 28. Nat Chem Biol. 2023. PMID: 36577875 Free PMC article.
DUBs, the regulation of cell identity and disease.
Heideker J, Wertz IE. Heideker J, et al. Among authors: wertz ie. Biochem J. 2015 Jan 1;465(1):1-26. doi: 10.1042/BJ20140496. Biochem J. 2015. PMID: 25631680 Review.
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE. Kategaya L, et al. Among authors: wertz ie. Nature. 2017 Oct 26;550(7677):534-538. doi: 10.1038/nature24006. Epub 2017 Oct 18. Nature. 2017. PMID: 29045385
Ubiquitination in the regulation of inflammatory cell death and cancer.
Cockram PE, Kist M, Prakash S, Chen SH, Wertz IE, Vucic D. Cockram PE, et al. Among authors: wertz ie. Cell Death Differ. 2021 Feb;28(2):591-605. doi: 10.1038/s41418-020-00708-5. Epub 2021 Jan 11. Cell Death Differ. 2021. PMID: 33432113 Free PMC article. Review.
61 results