Westbroek W - Search Results

1

Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases.

Yap TL, Gruschus JM, Velayati A, Westbroek W, Goldin E, Moaven N, Sidransky E, Lee JC. Yap TL, et al. Among authors: westbroek w. J Biol Chem. 2011 Aug 12;286(32):28080-8. doi: 10.1074/jbc.M111.237859. Epub 2011 Jun 8. J Biol Chem. 2011. PMID: 21653695 Free PMC article.

2

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Marugan JJ, et al. Among authors: westbroek w. J Med Chem. 2011 Feb 24;54(4):1033-58. doi: 10.1021/jm1008902. Epub 2011 Jan 20. J Med Chem. 2011. PMID: 21250698 Free PMC article.

3

Exploring the link between glucocerebrosidase mutations and parkinsonism.

Westbroek W, Gustafson AM, Sidransky E. Westbroek W, et al. Trends Mol Med. 2011 Sep;17(9):485-93. doi: 10.1016/j.molmed.2011.05.003. Epub 2011 Jul 1. Trends Mol Med. 2011. PMID: 21723784 Free PMC article. Review.

4

A mutation in SCARB2 is a modifier in Gaucher disease.

Velayati A, DePaolo J, Gupta N, Choi JH, Moaven N, Westbroek W, Goker-Alpan O, Goldin E, Stubblefield BK, Kolodny E, Tayebi N, Sidransky E. Velayati A, et al. Among authors: westbroek w. Hum Mutat. 2011 Nov;32(11):1232-8. doi: 10.1002/humu.21566. Epub 2011 Sep 15. Hum Mutat. 2011. PMID: 21796727 Free PMC article.

5

Glucocerebrosidase is shaking up the synucleinopathies.

Siebert M, Sidransky E, Westbroek W. Siebert M, et al. Among authors: westbroek w. Brain. 2014 May;137(Pt 5):1304-22. doi: 10.1093/brain/awu002. Epub 2014 Feb 14. Brain. 2014. PMID: 24531622 Free PMC article. Review.

6

The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease.

Aflaki E, Westbroek W, Sidransky E. Aflaki E, et al. Among authors: westbroek w. Neuron. 2017 Feb 22;93(4):737-746. doi: 10.1016/j.neuron.2017.01.018. Neuron. 2017. PMID: 28231462 Free PMC article. Review.

7

Validation of anti-glucocerebrosidase antibodies for western blot analysis on protein lysates of murine and human cells.

Qi W, Davidson BA, Nguyen M, Lindstrom T, Grey RJ, Burnett R, Aflaki E, Sidransky E, Westbroek W. Qi W, et al. Among authors: westbroek w. Biochem J. 2019 Jan 25;476(2):261-274. doi: 10.1042/BCJ20180708. Biochem J. 2019. PMID: 30578288

8

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.

Patnaik S, Zheng W, Choi JH, Motabar O, Southall N, Westbroek W, Lea WA, Velayati A, Goldin E, Sidransky E, Leister W, Marugan JJ. Patnaik S, et al. Among authors: westbroek w. J Med Chem. 2012 Jun 28;55(12):5734-48. doi: 10.1021/jm300063b. Epub 2012 Jun 8. J Med Chem. 2012. PMID: 22646221 Free PMC article.

9

Identification of miRNAs that modulate glucocerebrosidase activity in Gaucher disease cells.

Siebert M, Westbroek W, Chen YC, Moaven N, Li Y, Velayati A, Saraiva-Pereira ML, Martin SE, Sidransky E. Siebert M, et al. Among authors: westbroek w. RNA Biol. 2014;11(10):1291-300. doi: 10.1080/15476286.2014.996085. RNA Biol. 2014. PMID: 25584808 Free PMC article.

10

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.

Aflaki E, Moaven N, Borger DK, Lopez G, Westbroek W, Chae JJ, Marugan J, Patnaik S, Maniwang E, Gonzalez AN, Sidransky E. Aflaki E, et al. Among authors: westbroek w. Aging Cell. 2016 Feb;15(1):77-88. doi: 10.1111/acel.12409. Epub 2015 Oct 21. Aging Cell. 2016. PMID: 26486234 Free PMC article.

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