Westwood R - Search Results

1

(Imidazo[1,2-a]pyrimidin-2-yl)phenylmethanones and related compounds as potential nonsedative anxiolytics.

Clements-Jewery S, Danswan G, Gardner CR, Matharu SS, Murdoch R, Tully WR, Westwood R. Clements-Jewery S, et al. Among authors: westwood r. J Med Chem. 1988 Jun;31(6):1220-6. doi: 10.1021/jm00401a025. J Med Chem. 1988. PMID: 2897468

2

Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.

Kuo EA, Hambleton PT, Kay DP, Evans PL, Matharu SS, Little E, McDowall N, Jones CB, Hedgecock CJ, Yea CM, Chan AW, Hairsine PW, Ager IR, Tully WR, Williamson RA, Westwood R. Kuo EA, et al. Among authors: westwood r. J Med Chem. 1996 Nov 8;39(23):4608-21. doi: 10.1021/jm9604437. J Med Chem. 1996. PMID: 8917650

3

2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors.

Tully WR, Gardner CR, Gillespie RJ, Westwood R. Tully WR, et al. Among authors: westwood r. J Med Chem. 1991 Jul;34(7):2060-7. doi: 10.1021/jm00111a021. J Med Chem. 1991. PMID: 1648620

4

Synthesis and antitussive activity of aminotetra- (and -hexa-) hydrodibenzofurans.

Matharu SS, Rowlands DA, Taylor JB, Westwood R. Matharu SS, et al. Among authors: westwood r. J Med Chem. 1977 Feb;20(2):197-204. doi: 10.1021/jm00212a003. J Med Chem. 1977. PMID: 836490

5

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound.

Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Moss D, Thomson TA, Spinella-Jaegle S, Morand P, Courtin O, Sautés C, Westwood R, Hercend T, Kuo EA, Ruuth E. Williamson RA, et al. Among authors: westwood r. J Biol Chem. 1995 Sep 22;270(38):22467-72. doi: 10.1074/jbc.270.38.22467. J Biol Chem. 1995. PMID: 7673235 Free article.

6

Potencies of leflunomide and HR325 as inhibitors of prostaglandin endoperoxide H synthase-1 and -2: comparison with nonsteroidal anti-inflammatory drugs.

Curnock AP, Robson PA, Yea CM, Moss D, Gadher S, Thomson TA, Westwood R, Ruuth E, Williamson RA. Curnock AP, et al. Among authors: westwood r. J Pharmacol Exp Ther. 1997 Jul;282(1):339-47. J Pharmacol Exp Ther. 1997. PMID: 9223572

7

Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide.

Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Spinella-Jaegle S, Morand P, Courtin O, Sautés C, Westwood R, Hercend T, Kuo EA, Ruuth E. Williamson RA, et al. Among authors: westwood r. Transplant Proc. 1996 Dec;28(6):3088-91. Transplant Proc. 1996. PMID: 8962196 No abstract available.

8

Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide.

Bruneau JM, Yea CM, Spinella-Jaegle S, Fudali C, Woodward K, Robson PA, Sautès C, Westwood R, Kuo EA, Williamson RA, Ruuth E. Bruneau JM, et al. Among authors: westwood r. Biochem J. 1998 Dec 1;336 ( Pt 2)(Pt 2):299-303. doi: 10.1042/bj3360299. Biochem J. 1998. PMID: 9820804 Free PMC article.

9

Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325.

Curnock AP, Thomson TA, Westwood R, Kuo EA, Williamson RA, Yea CM, Ruuthb E. Curnock AP, et al. Among authors: westwood r. Biochem Pharmacol. 2001 Jan 15;61(2):227-35. doi: 10.1016/s0006-2952(00)00552-9. Biochem Pharmacol. 2001. PMID: 11163337

10

Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.

Wilson SC, Atrash B, Barlow C, Eccles S, Fischer PM, Hayes A, Kelland L, Jackson W, Jarman M, Mirza A, Moreno J, Nutley BP, Raynaud FI, Sheldrake P, Walton M, Westwood R, Whittaker S, Workman P, McDonald E. Wilson SC, et al. Among authors: westwood r. Bioorg Med Chem. 2011 Nov 15;19(22):6949-65. doi: 10.1016/j.bmc.2011.08.051. Epub 2011 Aug 31. Bioorg Med Chem. 2011. PMID: 21982796

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