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Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.
Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, Caron MG, Javitch JA, Roth BL, Jin J. Allen JA, et al. Among authors: wetsel wc. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. doi: 10.1073/pnas.1104807108. Epub 2011 Oct 24. Proc Natl Acad Sci U S A. 2011. PMID: 22025698 Free PMC article.
Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.
Ade KK, Wan Y, Hamann HC, O'Hare JK, Guo W, Quian A, Kumar S, Bhagat S, Rodriguiz RM, Wetsel WC, Conn PJ, Dzirasa K, Huber KM, Calakos N. Ade KK, et al. Among authors: wetsel wc. Biol Psychiatry. 2016 Oct 1;80(7):522-33. doi: 10.1016/j.biopsych.2016.04.023. Epub 2016 May 13. Biol Psychiatry. 2016. PMID: 27436084 Free PMC article.
Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG. Urs NM, et al. Among authors: wetsel wc. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8178-E8186. doi: 10.1073/pnas.1614347113. Epub 2016 Dec 1. Proc Natl Acad Sci U S A. 2016. PMID: 27911814 Free PMC article.
210 results