What dose of tranexamic acid is most effective and safe for adult patients undergoing cardiac surgery?
Interact Cardiovasc Thorac Surg. 2015.
PMID: 26015509
Review.
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What dose of tranexamic acid is most effective and safe for adult patients undergoing cardiac surgery?
Interact Cardiovasc Thorac Surg. 2015 Sep;21(3):384-8. doi: 10.1093/icvts/ivv134. Epub 2015 May 25.
Interact Cardiovasc Thorac Surg. 2015.
PMID: 26015509
Review.
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: what dose of tranexamic acid is most effective and safe for adult patients undergoing card …
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: what d …
Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass.
Anaesthesia. 2012 Nov;67(11):1242-50. doi: 10.1111/j.1365-2044.2012.07266.x. Epub 2012 Jul 24.
Anaesthesia. 2012.
PMID: 22827564
Free article.
We conducted a study to assess pharmacokinetics of high-dose tranexamic acid for 24 h after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary bypass. ...With recent studies implicating high-d …
We conducted a study to assess pharmacokinetics of high-dose tranexamic acid for 24 h after administration of the drug …
Postoperative thrombotic effects of tranexamic acid in open heart surgery.
Ir J Med Sci. 2019 Nov;188(4):1373-1378. doi: 10.1007/s11845-019-01991-z. Epub 2019 Feb 28.
Ir J Med Sci. 2019.
PMID: 30815786
AIMS: In this retrospective cohort study, we aimed to determine the possible thromboembolic complications due to tranexamic acid as a prophylactic method in patients undergoing open heart surgery. METHODS: The data of 172 adult patient …
AIMS: In this retrospective cohort study, we aimed to determine the possible thromboembolic complications due to tranexamic acid …
Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment.
Biopharm Drug Dispos. 2015 Jul;36(5):294-307. doi: 10.1002/bdd.1941. Epub 2015 Apr 21.
Biopharm Drug Dispos. 2015.
PMID: 25704361
Free article.
Tranexamic acid (TXA), an effective anti-fibrinolytic agent that is cleared by glomerular filtration, is used widely for cardiopulmonary bypass (CPB) surgery. However, an effective dosing regimen has not been fully developed in patients w …
Tranexamic acid (TXA), an effective anti-fibrinolytic agent that is cleared by glomerular filtration, is used widely fo …
Is tranexamic acid safe in patients undergoing coronary endarterectomy?
Ann Thorac Surg. 2001 May;71(5):1508-11. doi: 10.1016/s0003-4975(01)02459-6.
Ann Thorac Surg. 2001.
PMID: 11383791
Data assessing the safety of the antifibrinolytic drug tranexamic acid (TA) in patients undergoing this procedure are lacking. ...CONCLUSIONS: These results suggest that the clinical effectiveness of tranexamic acid in reducing pos …
Data assessing the safety of the antifibrinolytic drug tranexamic acid (TA) in patients undergoing this procedur …
Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis.
Crit Care. 2010;14(4):R148. doi: 10.1186/cc9216. Epub 2010 Aug 3.
Crit Care. 2010.
PMID: 20682059
Free PMC article.
Since then, tranexamic acid (TXA) has become the antifibrinolytic treatment of choice in many heart centers. ...Therefore, the aim of this study was to evaluate safety and efficiency of TXA compared with aprotinin in cardiac surgery. METHODS: Since Jul …
Since then, tranexamic acid (TXA) has become the antifibrinolytic treatment of choice in many heart centers. ...Therefore, the …
Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study.
Spine (Phila Pa 1976). 2008 Nov 15;33(24):2577-80. doi: 10.1097/BRS.0b013e318188b9c5.
Spine (Phila Pa 1976). 2008.
PMID: 19011538
Clinical Trial.
STUDY DESIGN: This is a double blind randomized placebo controlled study, after obtaining approval of ethics committee in the hospital and informed written consent, 64 patients were randomized equally into 2 groups (tranexamic acid (TA) and placebo). ...Short …
STUDY DESIGN: This is a double blind randomized placebo controlled study, after obtaining approval of ethics committee in the hospital and i …
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