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Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity.
Sniecikowska J, Gluch-Lutwin M, Bucki A, Więckowska A, Siwek A, Jastrzebska-Wiesek M, Partyka A, Wilczyńska D, Pytka K, Pociecha K, Cios A, Wyska E, Wesołowska A, Pawłowski M, Varney MA, Newman-Tancredi A, Kolaczkowski M. Sniecikowska J, et al. Among authors: wieckowska a. J Med Chem. 2019 Mar 14;62(5):2750-2771. doi: 10.1021/acs.jmedchem.9b00062. Epub 2019 Mar 2. J Med Chem. 2019. PMID: 30721053
Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile.
Sniecikowska J, Gluch-Lutwin M, Bucki A, Więckowska A, Siwek A, Jastrzebska-Wiesek M, Partyka A, Wilczyńska D, Pytka K, Latacz G, Przejczowska-Pomierny K, Wyska E, Wesołowska A, Pawłowski M, Newman-Tancredi A, Kolaczkowski M. Sniecikowska J, et al. Among authors: wieckowska a. J Med Chem. 2020 Oct 8;63(19):10946-10971. doi: 10.1021/acs.jmedchem.0c00814. Epub 2020 Sep 23. J Med Chem. 2020. PMID: 32883072 Free PMC article.
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
Szałaj N, Godyń J, Jończyk J, Pasieka A, Panek D, Wichur T, Więckowski K, Zaręba P, Bajda M, Pislar A, Malawska B, Sabate R, Więckowska A. Szałaj N, et al. Among authors: wieckowska a. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1944-1952. doi: 10.1080/14756366.2020.1835882. J Enzyme Inhib Med Chem. 2020. PMID: 33092411 Free PMC article.
In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases.
Więckowska A, Szałaj N, Góral I, Bucki A, Latacz G, Kiec-Kononowicz K, Bautista-Aguilera ÒM, Romero A, Ramos E, Egea J, Farré Alíns V, González-Rodríguez Á, López-Muñoz F, Chioua M, Marco-Contelles J. Więckowska A, et al. ACS Chem Neurosci. 2020 Nov 18;11(22):3793-3801. doi: 10.1021/acschemneuro.0c00489. Epub 2020 Nov 3. ACS Chem Neurosci. 2020. PMID: 33143412 Free PMC article.
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.
Pasieka A, Panek D, Jończyk J, Godyń J, Szałaj N, Latacz G, Tabor J, Mezeiova E, Chantegreil F, Dias J, Knez D, Lu J, Pi R, Korabecny J, Brazzolotto X, Gobec S, Höfner G, Wanner K, Więckowska A, Malawska B. Pasieka A, et al. Among authors: wieckowska a. Eur J Med Chem. 2021 Jun 5;218:113397. doi: 10.1016/j.ejmech.2021.113397. Epub 2021 Mar 31. Eur J Med Chem. 2021. PMID: 33838585
Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer's Agents.
Pasieka A, Panek D, Szałaj N, Espargaró A, Więckowska A, Malawska B, Sabaté R, Bajda M. Pasieka A, et al. Among authors: wieckowska a. ACS Chem Neurosci. 2021 Jun 2;12(11):2057-2068. doi: 10.1021/acschemneuro.1c00235. Epub 2021 May 21. ACS Chem Neurosci. 2021. PMID: 34019757 Free PMC article.
Bacterial type I signal peptidase inhibitors - Optimized hits from nature.
Szałaj N, Benediktsdottir A, Rusin D, Karlén A, Mowbray SL, Więckowska A. Szałaj N, et al. Among authors: wieckowska a. Eur J Med Chem. 2022 Aug 5;238:114490. doi: 10.1016/j.ejmech.2022.114490. Epub 2022 May 26. Eur J Med Chem. 2022. PMID: 35660251 Review.
83 results