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Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.
Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. Tukulula M, et al. Among authors: wiesner l. ACS Med Chem Lett. 2013 Oct 1;4(12):1198-202. doi: 10.1021/ml400311r. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900630 Free PMC article.
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice.
Melariri P, Kalombo L, Nkuna P, Dube A, Hayeshi R, Ogutu B, Gibhard L, deKock C, Smith P, Wiesner L, Swai H. Melariri P, et al. Among authors: wiesner l. Int J Nanomedicine. 2015 Feb 20;10:1493-503. doi: 10.2147/IJN.S76317. eCollection 2015. Int J Nanomedicine. 2015. PMID: 25759576 Free PMC article.
In Vitro and In Vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102.
Gibhard L, Pravin K, Abay E, Wilhelm A, Swart K, Lawrence N, Khoury R, van der Westhuizen J, Smith P, Wiesner L. Gibhard L, et al. Among authors: wiesner l. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3065-9. doi: 10.1128/AAC.02104-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26953201 Free PMC article.
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.
Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK. Coertzen D, et al. Among authors: wiesner l. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e02214-17. doi: 10.1128/AAC.02214-17. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29866868 Free PMC article.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Gibhard L, Njoroge M, Paquet T, Brunschwig C, Taylor D, Lawrence N, Abay E, Wittlin S, Wiesner L, Street LJ, Chibale K, Basarab GS. Gibhard L, et al. Among authors: wiesner l. Antimicrob Agents Chemother. 2018 Nov 26;62(12):e00261-18. doi: 10.1128/AAC.00261-18. Print 2018 Dec. Antimicrob Agents Chemother. 2018. PMID: 30249687 Free PMC article.
305 results