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A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATP.
Wiley JS, Gu BJ. Wiley JS, et al. Purinergic Signal. 2012 Sep;8(3):579-86. doi: 10.1007/s11302-012-9308-5. Epub 2012 Apr 4. Purinergic Signal. 2012. PMID: 22476940 Free PMC article. Review.
The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases.
Ou A, Gu BJ, Wiley JS. Ou A, et al. Among authors: wiley js. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1051-1059. doi: 10.1016/j.bbadis.2018.01.012. Epub 2018 Jan 9. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29329985 Free article.
Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice: A Novel Model for Investigating the Early Pathogenesis of Age-Related Macular Degeneration.
Vessey KA, Gu BJ, Jobling AI, Phipps JA, Greferath U, Tran MX, Dixon MA, Baird PN, Guymer RH, Wiley JS, Fletcher EL. Vessey KA, et al. Among authors: wiley js. Am J Pathol. 2017 Aug;187(8):1670-1685. doi: 10.1016/j.ajpath.2017.04.016. Epub 2017 Jun 17. Am J Pathol. 2017. PMID: 28628761 Free article.
Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease.
Gu BJ, Huang X, Ou A, Rembach A, Fowler C, Avula PK, Horton A, Doecke JD, Villemagne VL, Macaulay SL, Maruff P, Fletcher EL, Guymer R, Wiley JS, Masters CL; Australian Imaging, Biomarkers and Lifestyle (AIBL) Study. Gu BJ, et al. Among authors: wiley js. Acta Neuropathol. 2016 Sep;132(3):377-89. doi: 10.1007/s00401-016-1596-3. Epub 2016 Jul 13. Acta Neuropathol. 2016. PMID: 27411339
A quantitative method for measuring innate phagocytosis by human monocytes using real-time flow cytometry.
Gu BJ, Sun C, Fuller S, Skarratt KK, Petrou S, Wiley JS. Gu BJ, et al. Among authors: wiley js. Cytometry A. 2014 Apr;85(4):313-21. doi: 10.1002/cyto.a.22400. Epub 2013 Oct 16. Cytometry A. 2014. PMID: 24132941
P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts.
Lovelace MD, Gu BJ, Eamegdool SS, Weible MW 2nd, Wiley JS, Allen DG, Chan-Ling T. Lovelace MD, et al. Among authors: wiley js. Stem Cells. 2015 Feb;33(2):526-41. doi: 10.1002/stem.1864. Stem Cells. 2015. PMID: 25336287
Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis.
Sadovnick AD, Gu BJ, Traboulsee AL, Bernales CQ, Encarnacion M, Yee IM, Criscuoli MG, Huang X, Ou A, Milligan CJ, Petrou S, Wiley JS, Vilariño-Güell C. Sadovnick AD, et al. Among authors: wiley js. Hum Mutat. 2017 Jun;38(6):736-744. doi: 10.1002/humu.23218. Epub 2017 Apr 13. Hum Mutat. 2017. PMID: 28326637 Free PMC article.
Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis.
Miller CM, Zakrzewski AM, Robinson DP, Fuller SJ, Walker RA, Ikin RJ, Bao SJ, Grigg ME, Wiley JS, Smith NC. Miller CM, et al. Among authors: wiley js. PLoS One. 2015 Jun 8;10(6):e0129048. doi: 10.1371/journal.pone.0129048. eCollection 2015. PLoS One. 2015. PMID: 26053862 Free PMC article.
P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid.
Gu BJ, Duce JA, Valova VA, Wong B, Bush AI, Petrou S, Wiley JS. Gu BJ, et al. Among authors: wiley js. J Biol Chem. 2012 May 18;287(21):17318-30. doi: 10.1074/jbc.M112.340885. Epub 2012 Mar 29. J Biol Chem. 2012. PMID: 22461619 Free PMC article.
The role of the P2X₇ receptor in infectious diseases.
Miller CM, Boulter NR, Fuller SJ, Zakrzewski AM, Lees MP, Saunders BM, Wiley JS, Smith NC. Miller CM, et al. Among authors: wiley js. PLoS Pathog. 2011 Nov;7(11):e1002212. doi: 10.1371/journal.ppat.1002212. Epub 2011 Nov 10. PLoS Pathog. 2011. PMID: 22102807 Free PMC article. Review.
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