Willson TM - Search Results

1

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A. Müller S, et al. Among authors: willson tm. Elife. 2018 Apr 20;7:e34311. doi: 10.7554/eLife.34311. Elife. 2018. PMID: 29676732 Free PMC article.

2

The PPARs: from orphan receptors to drug discovery.

Willson TM, Brown PJ, Sternbach DD, Henke BR. Willson TM, et al. J Med Chem. 2000 Feb 24;43(4):527-50. doi: 10.1021/jm990554g. J Med Chem. 2000. PMID: 10691680 Review. No abstract available.

3

Selection, application, and validation of a set of molecular descriptors for nuclear receptor ligands.

Stewart EL, Brown PJ, Bentley JA, Willson TM. Stewart EL, et al. Among authors: willson tm. Comb Chem High Throughput Screen. 2004 Aug;7(5):407-12. doi: 10.2174/1386207043328535. Comb Chem High Throughput Screen. 2004. PMID: 15320707

4

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT. Wang L, et al. Among authors: willson tm. J Biol Chem. 2006 Dec 8;281(49):37773-81. doi: 10.1074/jbc.M608410200. Epub 2006 Sep 21. J Biol Chem. 2006. PMID: 16990259 Free article.

5

Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.

Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Xue Y, et al. Among authors: willson tm. Bioorg Med Chem. 2007 Mar 1;15(5):2156-66. doi: 10.1016/j.bmc.2006.12.026. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17215127 Free PMC article.

6

On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.

Hyatt SM, Lockamy EL, Stein RA, McDonnell DP, Miller AB, Orband-Miller LA, Willson TM, Zuercher WJ. Hyatt SM, et al. Among authors: willson tm. J Med Chem. 2007 Dec 27;50(26):6722-4. doi: 10.1021/jm7012387. Epub 2007 Dec 4. J Med Chem. 2007. PMID: 18052088 Free PMC article.

7

Open access chemical and clinical probes to support drug discovery.

Edwards AM, Bountra C, Kerr DJ, Willson TM. Edwards AM, et al. Among authors: willson tm. Nat Chem Biol. 2009 Jul;5(7):436-40. doi: 10.1038/nchembio0709-436. Nat Chem Biol. 2009. PMID: 19536100

8

GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

Grant D, Yin L, Collins JL, Parks DJ, Orband-Miller LA, Wisely GB, Joshi S, Lazar MA, Willson TM, Zuercher WJ. Grant D, et al. Among authors: willson tm. ACS Chem Biol. 2010 Oct 15;5(10):925-32. doi: 10.1021/cb100141y. ACS Chem Biol. 2010. PMID: 20677822

9

Too many roads not taken.

Edwards AM, Isserlin R, Bader GD, Frye SV, Willson TM, Yu FH. Edwards AM, et al. Among authors: willson tm. Nature. 2011 Feb 10;470(7333):163-5. doi: 10.1038/470163a. Nature. 2011. PMID: 21307913 No abstract available.

10

Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.

Miao J, Choi SE, Seok SM, Yang L, Zuercher WJ, Xu Y, Willson TM, Xu HE, Kemper JK. Miao J, et al. Among authors: willson tm. Mol Endocrinol. 2011 Jul;25(7):1159-69. doi: 10.1210/me.2011-0033. Epub 2011 May 12. Mol Endocrinol. 2011. PMID: 21566081 Free PMC article.

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