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Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium; Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium. Wiseman FK, et al. Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Brain. 2018. PMID: 29945247 Free PMC article.
Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21.
Mumford P, Tosh J, Anderle S, Gkanatsiou Wikberg E, Lau G, Noy S, Cleverley K, Saito T, Saido TC, Yu E, Brinkmalm G, Portelius E, Blennow K, Zetterberg H, Tybulewicz V, Fisher EMC, Wiseman FK. Mumford P, et al. Among authors: wiseman fk. J Neurosci. 2022 Aug 17;42(33):6453-6468. doi: 10.1523/JNEUROSCI.0521-22.2022. Epub 2022 Jul 14. J Neurosci. 2022. PMID: 35835549 Free PMC article.
Down syndrome--recent progress and future prospects.
Wiseman FK, Alford KA, Tybulewicz VL, Fisher EM. Wiseman FK, et al. Hum Mol Genet. 2009 Apr 15;18(R1):R75-83. doi: 10.1093/hmg/ddp010. Hum Mol Genet. 2009. PMID: 19297404 Free PMC article. Review.
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK. Sheppard O, et al. Among authors: wiseman fk. Neurobiol Aging. 2012 Apr;33(4):828.e31-44. doi: 10.1016/j.neurobiolaging.2011.06.025. Epub 2011 Aug 16. Neurobiol Aging. 2012. PMID: 21843906 Free PMC article.
Mouse models of aneuploidy.
Sheppard O, Wiseman FK, Ruparelia A, Tybulewicz VL, Fisher EM. Sheppard O, et al. Among authors: wiseman fk. ScientificWorldJournal. 2012;2012:214078. doi: 10.1100/2012/214078. Epub 2012 Jan 3. ScientificWorldJournal. 2012. PMID: 22262951 Free PMC article. Review.
38 results