Witting PK - Search Results

1

Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress.

Stapelberg M, Gellert N, Swettenham E, Tomasetti M, Witting PK, Procopio A, Neuzil J. Stapelberg M, et al. Among authors: witting pk. J Biol Chem. 2005 Jul 8;280(27):25369-76. doi: 10.1074/jbc.M414498200. Epub 2005 May 5. J Biol Chem. 2005. PMID: 15878867 Free article.

2

Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system?

Swettenham E, Witting PK, Salvatore BA, Neuzil J. Swettenham E, et al. Among authors: witting pk. J Neurochem. 2005 Sep;94(5):1448-56. doi: 10.1111/j.1471-4159.2005.03298.x. Epub 2005 Jul 7. J Neurochem. 2005. PMID: 16001965 Free article.

3

Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury.

Neuzil J, Widén C, Gellert N, Swettenham E, Zobalova R, Dong LF, Wang XF, Lidebjer C, Dalen H, Headrick JP, Witting PK. Neuzil J, et al. Among authors: witting pk. Redox Rep. 2007;12(3):148-62. doi: 10.1179/135100007X200227. Redox Rep. 2007. PMID: 17623522

4

Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress.

Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, Stantic M, Low P, Prochazka L, Witting PK, Turanek J, Akporiaye ET, Ralph SJ, Neuzil J. Dong LF, et al. Among authors: witting pk. Cancer Res. 2007 Dec 15;67(24):11906-13. doi: 10.1158/0008-5472.CAN-07-3034. Cancer Res. 2007. PMID: 18089821

5

Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II.

Dong LF, Jameson VJ, Tilly D, Cerny J, Mahdavian E, Marín-Hernández A, Hernández-Esquivel L, Rodríguez-Enríquez S, Stursa J, Witting PK, Stantic B, Rohlena J, Truksa J, Kluckova K, Dyason JC, Ledvina M, Salvatore BA, Moreno-Sánchez R, Coster MJ, Ralph SJ, Smith RA, Neuzil J. Dong LF, et al. Among authors: witting pk. J Biol Chem. 2011 Feb 4;286(5):3717-28. doi: 10.1074/jbc.M110.186643. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059645 Free PMC article.

6

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway.

Wang XF, Witting PK, Salvatore BA, Neuzil J. Wang XF, et al. Among authors: witting pk. Biochem Biophys Res Commun. 2005 Jan 14;326(2):282-9. doi: 10.1016/j.bbrc.2004.11.028. Biochem Biophys Res Commun. 2005. PMID: 15582575

7

Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II.

Dong LF, Low P, Dyason JC, Wang XF, Prochazka L, Witting PK, Freeman R, Swettenham E, Valis K, Liu J, Zobalova R, Turanek J, Spitz DR, Domann FE, Scheffler IE, Ralph SJ, Neuzil J. Dong LF, et al. Among authors: witting pk. Oncogene. 2008 Jul 17;27(31):4324-35. doi: 10.1038/onc.2008.69. Epub 2008 Mar 31. Oncogene. 2008. PMID: 18372923 Free PMC article.

8

Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research.

Neuzil J, Rayner BS, Lowe HC, Witting PK. Neuzil J, et al. Among authors: witting pk. Redox Rep. 2005;10(4):187-97. doi: 10.1179/135100005X57391. Redox Rep. 2005. PMID: 16259786 Review.

9

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Valis K, Rodriguez-Enriquez S, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler IE, Ralph SJ, Neuzil J. Dong LF, et al. Among authors: witting pk. Clin Cancer Res. 2009 Mar 1;15(5):1593-600. doi: 10.1158/1078-0432.CCR-08-2439. Epub 2009 Feb 17. Clin Cancer Res. 2009. PMID: 19223492

10

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy.

Dong LF, Jameson VJ, Tilly D, Prochazka L, Rohlena J, Valis K, Truksa J, Zobalova R, Mahdavian E, Kluckova K, Stantic M, Stursa J, Freeman R, Witting PK, Norberg E, Goodwin J, Salvatore BA, Novotna J, Turanek J, Ledvina M, Hozak P, Zhivotovsky B, Coster MJ, Ralph SJ, Smith RA, Neuzil J. Dong LF, et al. Among authors: witting pk. Free Radic Biol Med. 2011 Jun 1;50(11):1546-55. doi: 10.1016/j.freeradbiomed.2011.02.032. Epub 2011 Mar 12. Free Radic Biol Med. 2011. PMID: 21402148

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