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Year Number of Results
1987 1
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3,934 results

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Page 1
The Wnt1-Cre2 transgene is active in the male germline.
Dinsmore CJ, Ke CY, Soriano P. Dinsmore CJ, et al. Genesis. 2022 Mar;60(3):e23468. doi: 10.1002/dvg.23468. Epub 2022 Feb 18. Genesis. 2022. PMID: 35180326 Free PMC article.
The Wnt1-Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WNT1 itself, which can cause undesired phenotypes. To address this, we and others previously developed a Wnt1-Cre2 line based on th …
The Wnt1-Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WN …
Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus.
Company V, Moreno-Cerdá A, Andreu-Cervera A, Murcia-Ramón R, Almagro-García F, Echevarría D, Martínez S, Puelles E. Company V, et al. Front Cell Dev Biol. 2021 Oct 14;9:755729. doi: 10.3389/fcell.2021.755729. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34722541 Free PMC article.
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. ...Wnt1 expressed in the isthmic organizer is vital to induce the midbrain and rostral hindbrain territories. ...
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central …
Wnt1 Boosts Fracture Healing by Enhancing Bone Formation in the Fracture Callus.
Haffner-Luntzer M, Ragipoglu D, Ahmad M, Schoppa A, Steppe L, Fischer V, Luther J, Yorgan T, Bockamp E, Amling M, Schinke T, Ignatius A. Haffner-Luntzer M, et al. J Bone Miner Res. 2023 May;38(5):749-764. doi: 10.1002/jbmr.4797. Epub 2023 Mar 22. J Bone Miner Res. 2023. PMID: 36891752 Free article.
Transgenic mice for a temporary induction of Wnt1 specifically in osteoblasts (Wnt1-tg) were subjected to femur osteotomy. ...To further test a potential translational application of Wnt1, we applied recombinant Wnt1 embedded into a collagen gel during …
Transgenic mice for a temporary induction of Wnt1 specifically in osteoblasts (Wnt1-tg) were subjected to femur osteotomy. ... …
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development.
Wurst W, Prakash N. Wurst W, et al. J Mol Cell Biol. 2014 Feb;6(1):34-41. doi: 10.1093/jmcb/mjt046. Epub 2013 Dec 9. J Mol Cell Biol. 2014. PMID: 24326514 Review.
Researches during the last decade revealed the pivotal role of the secreted Wnt1 ligand and its signalling cascade in the generation of the dopamine-synthesizing neurons in the mammalian VM. Here, we summarize the initial and more recent findings that have unravelled sever …
Researches during the last decade revealed the pivotal role of the secreted Wnt1 ligand and its signalling cascade in the generation …
Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner.
Nottmeier C, Liao N, Simon A, Decker MG, Luther J, Schweizer M, Yorgan T, Kaucka M, Bockamp E, Kahl-Nieke B, Amling M, Schinke T, Petersen J, Koehne T. Nottmeier C, et al. J Dent Res. 2021 Dec;100(13):1501-1509. doi: 10.1177/00220345211012386. Epub 2021 May 19. J Dent Res. 2021. PMID: 34009051 Free PMC article.
Micro-computed tomography (CT) analyses of the mandibles revealed a 1.8-fold increased bone volume after 1 and 3 wk of Wnt1 expression and a 3-fold increased bone volume after 9 wk of Wnt1 expression compared to controls. ...To further investigate the effect of W …
Micro-computed tomography (CT) analyses of the mandibles revealed a 1.8-fold increased bone volume after 1 and 3 wk of Wnt1 expressio …
Osteoblastic Wnt1 regulates periosteal bone formation in adult mice.
Wang F, Rummukainen P, Heino TJ, Kiviranta R. Wang F, et al. Bone. 2021 Feb;143:115754. doi: 10.1016/j.bone.2020.115754. Epub 2020 Nov 13. Bone. 2021. PMID: 33189914 Free article.
However, the function of Wnt1 in mature skeleton remained unknown. To investigate the role of Wnt1 specifically in adult bone metabolism, we generated an osteoblast lineage-targeted inducible Wnt1 knockout mouse model using tetracycline-controlled Osterix-Cre …
However, the function of Wnt1 in mature skeleton remained unknown. To investigate the role of Wnt1 specifically in adult bone …
WNT1 expression influences the development of dysplasia of the hip via regulating RBPMS2/NOG-BMP2/4-GDF5- WISP2 pathway.
Xu J, Ye W, Li H, Xu L. Xu J, et al. Nucleosides Nucleotides Nucleic Acids. 2022;41(8):765-777. doi: 10.1080/15257770.2022.2081337. Epub 2022 Jun 8. Nucleosides Nucleotides Nucleic Acids. 2022. PMID: 35675541
In chondrocytes, knockdown of WNT1 upregulated NOG expression, while overexpression of WNT1 downregulated its expression. ...Therefore, WNT1 may be a new therapeutic target for DDH....
In chondrocytes, knockdown of WNT1 upregulated NOG expression, while overexpression of WNT1 downregulated its expression. ...T …
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand.
Luther J, Yorgan TA, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D, Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S, Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David JP. Luther J, et al. Sci Transl Med. 2018 Nov 7;10(466):eaau7137. doi: 10.1126/scitranslmed.aau7137. Sci Transl Med. 2018. PMID: 30404864
WNT1 mutations in humans are associated with a new form of osteogenesis imperfecta and with early-onset osteoporosis, suggesting a key role of WNT1 in bone mass regulation. ...The identification of Wnt1 as a regulator of bone formation and remodeling provides …
WNT1 mutations in humans are associated with a new form of osteogenesis imperfecta and with early-onset osteoporosis, suggesting a ke …
Wnt1/beta-catenin signaling upregulates spinal VGLUT2 expression to control neuropathic pain in mice.
Zhang ZL, Yu G, Peng J, Wang HB, Li YL, Liang XN, Su RB, Gong ZH. Zhang ZL, et al. Neuropharmacology. 2020 Mar 1;164:107869. doi: 10.1016/j.neuropharm.2019.107869. Epub 2019 Nov 27. Neuropharmacology. 2020. PMID: 31785260
In this study, we report that spared nerve injury induced an upregulation of VGLUT2 in the spinal cord, and intrathecal administration of small hairpin RNAs (shRNA) against VGLUT2 before or after surgery attenuated mechanical allodynia, and pathologically-enhanced glutamate relea …
In this study, we report that spared nerve injury induced an upregulation of VGLUT2 in the spinal cord, and intrathecal administration of sm …
Comprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases.
Peng C, Lu Y, Ren X, Wang Y, Zhang S, Chen M, Liu J, Fang F, Li T, Han J. Peng C, et al. Intractable Rare Dis Res. 2020 Feb;9(1):14-22. doi: 10.5582/irdr.2020.01018. Intractable Rare Dis Res. 2020. PMID: 32201670 Free PMC article.
This study has summarized diseases and mutations related to Wnt1. Wnt1 is involved in various cancers, genetic type XV osteogenesis imperfecta, osteoporosis, and neurological diseases. ...Wnt1 and other Wnt1-related proteins and signaling pathways may …
This study has summarized diseases and mutations related to Wnt1. Wnt1 is involved in various cancers, genetic type XV osteoge …
3,934 results