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Year Number of Results
1992 1
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2001 10
2002 13
2003 5
2004 5
2005 11
2006 10
2007 10
2008 18
2009 9
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274 results

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Page 1
Expression and Function of WNT6: From Development to Disease.
Wei M, Zhang C, Tian Y, Du X, Wang Q, Zhao H. Wei M, et al. Front Cell Dev Biol. 2020 Dec 9;8:558155. doi: 10.3389/fcell.2020.558155. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33425886 Free PMC article. Review.
WNT6 functions in mice and humans. This review summarizes the current findings on the biological functions of WNT6, describing its involvement in regulating embryogenesis, decidualization, and organ development. ...Thus, due to its various functions, WNT6 has …
WNT6 functions in mice and humans. This review summarizes the current findings on the biological functions of WNT6, describing …
Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells.
Bonnet C, Oh D, Mei H, Robertson S, Chang D, Bourges JL, Behar-Cohen F, Zheng JJ, Deng SX. Bonnet C, et al. Sci Rep. 2021 Oct 22;11(1):20948. doi: 10.1038/s41598-021-00273-y. Sci Rep. 2021. PMID: 34686698 Free PMC article.
The corneal epithelium is consistently regenerated by limbal stem/progenitor cells (LSCs), a very small population of adult stem cells residing in the limbus. Several Wnt ligands, including Wnt6, are preferentially expressed in the limbus. To investigate the role of Wnt …
The corneal epithelium is consistently regenerated by limbal stem/progenitor cells (LSCs), a very small population of adult stem cells resid …
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
He QJ, Wang P, Liu QQ, Wu QG, Li YF, Wang J, Lee SC. He QJ, et al. Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C48-C62. doi: 10.1152/ajpcell.00091.2019. Epub 2019 Oct 16. Am J Physiol Cell Physiol. 2020. PMID: 31618077 Free article.
Treatment of cells with siRNA species for Wnt6, Frizzled-4 (FZD4), or beta-catenin as well as introduction of antibodies against Wnt6 or FZD4 to the cell culture medium could all attenuate the treatment-triggered centrosome amplification. ...Treatment of the cells w …
Treatment of cells with siRNA species for Wnt6, Frizzled-4 (FZD4), or beta-catenin as well as introduction of antibodies against W …
WNT6 is an effective marker for osteosarcoma diagnosis and prognosis.
Jiang K, Li S, Li L, Wang X, Gu Y, Jin Z. Jiang K, et al. Medicine (Baltimore). 2018 Nov;97(46):e13011. doi: 10.1097/MD.0000000000013011. Medicine (Baltimore). 2018. PMID: 30431574 Free PMC article.
Cox regression analysis was adopted to evaluate prognostic significance of WNT6 expression among osteosarcoma patients.Compared with the controls, WNT6 mRNA and protein levels were significantly elevated in patients with osteosarcoma (P > .05 for all). ...WNT6 …
Cox regression analysis was adopted to evaluate prognostic significance of WNT6 expression among osteosarcoma patients.Compared with …
Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J. Beaton H, et al. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45. doi: 10.1152/ajprenal.00136.2016. Epub 2016 Apr 27. Am J Physiol Renal Physiol. 2016. PMID: 27122540 Free article.
We have shown prominent Wnt6 and frizzled 7 (FzD7) expression in the mesonephros of the developing mouse kidney, suggesting a role for Wnt6 in epithelialization. ...FzD7 was identified as a putative receptor of Wnt6. In vitro Wnt6 expression leads to d …
We have shown prominent Wnt6 and frizzled 7 (FzD7) expression in the mesonephros of the developing mouse kidney, suggesting a role fo …
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma.
Gonçalves CS, Vieira de Castro J, Pojo M, Martins EP, Queirós S, Chautard E, Taipa R, Pires MM, Pinto AA, Pardal F, Custódia C, Faria CC, Clara C, Reis RM, Sousa N, Costa BM. Gonçalves CS, et al. Theranostics. 2018 Sep 9;8(17):4805-4823. doi: 10.7150/thno.25025. eCollection 2018. Theranostics. 2018. PMID: 30279739 Free PMC article.
While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. ...Mechanistically …
While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT …
High WNT6 expression indicates unfavorable survival outcome for patients with colorectal liver metastasis after liver resection.
Peng J, Zhao Y, Luo Q, Chen H, Fan W, Pan Z, Wang X, Zhang L. Peng J, et al. J Cancer. 2019 Jun 2;10(12):2619-2627. doi: 10.7150/jca.32817. eCollection 2019. J Cancer. 2019. PMID: 31258769 Free PMC article.
Survival analysis indicated that patients with high WNT6 expression had poorer 5-year OS than those with low WNT6 expression (31.0% vs. 62.2%, P = 0.012). ...Detection of WNT6 expression may be valuable for guiding postoperative treatment....
Survival analysis indicated that patients with high WNT6 expression had poorer 5-year OS than those with low WNT6 expression ( …
The glycoprotein Wnt6 regulates human dental papilla cells differentiation by canonical Wnt signaling pathway.
Fu H, Tan X, Ye L, Wang C. Fu H, et al. Arch Oral Biol. 2022 Sep;141:105469. doi: 10.1016/j.archoralbio.2022.105469. Epub 2022 Jun 3. Arch Oral Biol. 2022. PMID: 35691114
Wnt6 stealth RNA was used to knockdown the expression of Wnt6. The Wnt canonical signaling was detected by immunofluorescence staining, qPCR, and TOPflash/FOPflash dual-luciferase reporter assay. ...Wnt6 activated beta-catenin pathway in a similar way to Wnt3 …
Wnt6 stealth RNA was used to knockdown the expression of Wnt6. The Wnt canonical signaling was detected by immunofluorescence …
WNT6 participates in the occurrence and development of ovarian cancer by upregulating/activating the typical Wnt pathway and Notch1 signaling pathway.
Bao H, Wu W, Li Y, Zong Z, Chen S. Bao H, et al. Gene. 2022 Dec 20;846:146871. doi: 10.1016/j.gene.2022.146871. Epub 2022 Sep 6. Gene. 2022. PMID: 36075327
Further, we explored the possible role of WNT6 in the occurrence and development of ovarian cancer. Our results showed that the mRNA and protein expression of WNT6 were significantly higher in CAOV3 and OVCAR3 cells compared with other ovarian cancer cell lines and …
Further, we explored the possible role of WNT6 in the occurrence and development of ovarian cancer. Our results showed that the mRNA …
WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
Brandenburg J, Marwitz S, Tazoll SC, Waldow F, Kalsdorf B, Vierbuchen T, Scholzen T, Gross A, Goldenbaum S, Hölscher A, Hein M, Linnemann L, Reimann M, Kispert A, Leitges M, Rupp J, Lange C, Niemann S, Behrends J, Goldmann T, Heine H, Schaible UE, Hölscher C, Schwudke D, Reiling N. Brandenburg J, et al. J Clin Invest. 2021 Aug 16;131(16):e141833. doi: 10.1172/JCI141833. J Clin Invest. 2021. PMID: 34255743 Free PMC article.
Using genetic and pharmacological approaches, we demonstrated that lack of functional WNT6 or ACC2 significantly reduced intracellular triacylglycerol (TAG) levels and Mtb survival in macrophages. ...This combination also reduced Mtb bacterial numbers and the size of monon …
Using genetic and pharmacological approaches, we demonstrated that lack of functional WNT6 or ACC2 significantly reduced intracellula …
274 results