Woodroof HI - Search Results

1

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Kondapalli C, et al. Among authors: woodroof hi. Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080. Open Biol. 2012. PMID: 22724072 Free PMC article.

2

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Woodroof HI, et al. Open Biol. 2011 Nov;1(3):110012. doi: 10.1098/rsob.110012. Open Biol. 2011. PMID: 22645651 Free PMC article.

3

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM. Kazlauskaite A, et al. Among authors: woodroof hi. Open Biol. 2014 Mar 19;4(3):130213. doi: 10.1098/rsob.130213. Open Biol. 2014. PMID: 24647965 Free PMC article.

4

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

Lai YC, Kondapalli C, Lehneck R, Procter JB, Dill BD, Woodroof HI, Gourlay R, Peggie M, Macartney TJ, Corti O, Corvol JC, Campbell DG, Itzen A, Trost M, Muqit MM. Lai YC, et al. Among authors: woodroof hi. EMBO J. 2015 Nov 12;34(22):2840-61. doi: 10.15252/embj.201591593. Epub 2015 Oct 15. EMBO J. 2015. PMID: 26471730 Free PMC article.

5

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.

van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR. van der Wijst J, et al. Among authors: woodroof hi. Biochem J. 2014 Jun 1;460(2):165-75. doi: 10.1042/BJ20131639. Biochem J. 2014. PMID: 24650431 Free PMC article.

6

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.

Kumar A, Tamjar J, Waddell AD, Woodroof HI, Raimi OG, Shaw AM, Peggie M, Muqit MM, van Aalten DM. Kumar A, et al. Among authors: woodroof hi. Elife. 2017 Oct 5;6:e29985. doi: 10.7554/eLife.29985. Elife. 2017. PMID: 28980524 Free PMC article.

7

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.

Flinn LJ, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, Woodroof HI, Brown L, McTighe A, Soellner R, Allen CE, Heath PR, Milo M, Muqit MM, Reichert AS, Köster RW, Ingham PW, Bandmann O. Flinn LJ, et al. Among authors: woodroof hi. Ann Neurol. 2013 Dec;74(6):837-47. doi: 10.1002/ana.23999. Ann Neurol. 2013. PMID: 24027110 Free PMC article.

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