Wrighton SA - Search Results

1

Present and future in vitro approaches for drug metabolism.

Ekins S, Ring BJ, Grace J, McRobie-Belle DJ, Wrighton SA. Ekins S, et al. Among authors: wrighton sa. J Pharmacol Toxicol Methods. 2000 Jul-Aug;44(1):313-24. doi: 10.1016/s1056-8719(00)00110-6. J Pharmacol Toxicol Methods. 2000. PMID: 11274898 Review.

2

The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies.

Wrighton SA, Ring BJ, VandenBranden M. Wrighton SA, et al. Toxicol Pathol. 1995 Mar-Apr;23(2):199-208. doi: 10.1177/019262339502300214. Toxicol Pathol. 1995. PMID: 7569675 Review.

3

In vitro methods for assessing human hepatic drug metabolism: their use in drug development.

Wrighton SA, Vandenbranden M, Stevens JC, Shipley LA, Ring BJ, Rettie AE, Cashman JR. Wrighton SA, et al. Drug Metab Rev. 1993;25(4):453-84. doi: 10.3109/03602539308993982. Drug Metab Rev. 1993. PMID: 8313838 Review. No abstract available.

4

The human drug metabolizing cytochromes P450.

Wrighton SA, VandenBranden M, Ring BJ. Wrighton SA, et al. J Pharmacokinet Biopharm. 1996 Oct;24(5):461-73. doi: 10.1007/BF02353474. J Pharmacokinet Biopharm. 1996. PMID: 9131485 Review.

5

Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices.

VandenBranden M, Wrighton SA, Ekins S, Gillespie JS, Binkley SN, Ring BJ, Gadberry MG, Mullins DC, Strom SC, Jensen CB. VandenBranden M, et al. Among authors: wrighton sa. Drug Metab Dispos. 1998 Nov;26(11):1063-8. Drug Metab Dispos. 1998. PMID: 9806947

6

Predicting drug interactions and pharmacokinetic variability with in vitro methods: the olanzapine experience.

Wrighton SA, Ring BJ. Wrighton SA, et al. Drug Metab Rev. 1999 Feb;31(1):15-28. doi: 10.1081/dmr-100101905. Drug Metab Rev. 1999. PMID: 10065363 Review. No abstract available.

7

Progress in predicting human ADME parameters in silico.

Ekins S, Waller CL, Swaan PW, Cruciani G, Wrighton SA, Wikel JH. Ekins S, et al. Among authors: wrighton sa. J Pharmacol Toxicol Methods. 2000 Jul-Aug;44(1):251-72. doi: 10.1016/s1056-8719(00)00109-x. J Pharmacol Toxicol Methods. 2000. PMID: 11274894 Review.

8

Application of in silico approaches to predicting drug--drug interactions.

Ekins S, Wrighton SA. Ekins S, et al. Among authors: wrighton sa. J Pharmacol Toxicol Methods. 2001 Jan-Feb;45(1):65-9. doi: 10.1016/s1056-8719(01)00119-8. J Pharmacol Toxicol Methods. 2001. PMID: 11489666 Review.

9

A novel testosterone 6 beta-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro.

Fayer JL, Petullo DM, Ring BJ, Wrighton SA, Ruterbories KJ. Fayer JL, et al. Among authors: wrighton sa. J Pharmacol Toxicol Methods. 2001 Sep-Oct;46(2):117-23. doi: 10.1016/s1056-8719(02)00168-5. J Pharmacol Toxicol Methods. 2001. PMID: 12481849

10

The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450.

Ring BJ, Gillespie JS, Binkley SN, Campanale KM, Wrighton SA. Ring BJ, et al. Among authors: wrighton sa. Drug Metab Dispos. 2002 Sep;30(9):957-61. doi: 10.1124/dmd.30.9.957. Drug Metab Dispos. 2002. PMID: 12167559

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