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Rb is critical in a mammalian tissue stem cell population.
Wenzel PL, Wu L, de Bruin A, Chong JL, Chen WY, Dureska G, Sites E, Pan T, Sharma A, Huang K, Ridgway R, Mosaliganti K, Sharp R, Machiraju R, Saltz J, Yamamoto H, Cross JC, Robinson ML, Leone G. Wenzel PL, et al. Among authors: wu l. Genes Dev. 2007 Jan 1;21(1):85-97. doi: 10.1101/gad.1485307. Genes Dev. 2007. PMID: 17210791 Free PMC article.
Mouse development with a single E2F activator.
Tsai SY, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, Feria-Arias E, Timmers C, Opavska J, de Bruin A, Chong JL, Trikha P, Fernandez SA, Stromberg P, Rosol TJ, Leone G. Tsai SY, et al. Among authors: wu l. Nature. 2008 Aug 28;454(7208):1137-41. doi: 10.1038/nature07066. Epub 2008 Jun 25. Nature. 2008. PMID: 18594513 Free PMC article.
The E2F1-3 transcription factors are essential for cellular proliferation.
Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. Wu L, et al. Nature. 2001 Nov 22;414(6862):457-62. doi: 10.1038/35106593. Nature. 2001. PMID: 11719808
Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.
Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE, Sites E, Sandy A, Trimboli A, Fernandez SA, Eng C, Shapiro C, Leone G. Wu L, et al. Oncogene. 2015 Jan 2;34(1):119-28. doi: 10.1038/onc.2013.511. Epub 2013 Nov 25. Oncogene. 2015. PMID: 24276244 Free PMC article.
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