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Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors.
Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M. Didiasova M, et al. Among authors: wygrecka m. FASEB J. 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR. Epub 2017 Feb 1. FASEB J. 2017. PMID: 28148565
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our findings suggest that pirfenidone exerts its clinically beneficial effects through dual Hh/TGF-beta inhibition by targeting the GLI2 protei …
Because GLI transcription factors are not only crucial for Hh-mediated changes but are also required as mediators of TGF-beta signaling, our …
Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia.
Alejandre-Alcázar MA, Kwapiszewska G, Reiss I, Amarie OV, Marsh LM, Sevilla-Pérez J, Wygrecka M, Eul B, Köbrich S, Hesse M, Schermuly RT, Seeger W, Eickelberg O, Morty RE. Alejandre-Alcázar MA, et al. Among authors: wygrecka m. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L537-49. doi: 10.1152/ajplung.00050.2006. Epub 2006 Oct 27. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 17071723 Free article.
124 results