Xia D - Search Results

1

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities.

Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP. Sana G, et al. Among authors: xia d. J Invest Dermatol. 2019 Sep;139(9):1985-1992.e10. doi: 10.1016/j.jid.2019.01.036. Epub 2019 Mar 21. J Invest Dermatol. 2019. PMID: 30905807 Free PMC article.

2

The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.

Ambudkar SV, Kim IW, Xia D, Sauna ZE. Ambudkar SV, et al. Among authors: xia d. FEBS Lett. 2006 Feb 13;580(4):1049-55. doi: 10.1016/j.febslet.2005.12.051. Epub 2005 Dec 22. FEBS Lett. 2006. PMID: 16412422 Free article. Review.

3

The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.

Kim IW, Peng XH, Sauna ZE, FitzGerald PC, Xia D, Müller M, Nandigama K, Ambudkar SV. Kim IW, et al. Among authors: xia d. Biochemistry. 2006 Jun 20;45(24):7605-16. doi: 10.1021/bi060308o. Biochemistry. 2006. PMID: 16768456

4

Defeating drug resistance in cancer.

Gottesman MM, Ludwig J, Xia D, Szakács G. Gottesman MM, et al. Among authors: xia d. Discov Med. 2006 Feb;6(31):18-23. Discov Med. 2006. PMID: 17234123 Free article.

5

Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.

Sauna ZE, Bohn SS, Rutledge R, Dougherty MP, Cronin S, May L, Xia D, Ambudkar SV, Golin J. Sauna ZE, et al. Among authors: xia d. J Biol Chem. 2008 Dec 12;283(50):35010-22. doi: 10.1074/jbc.M806446200. Epub 2008 Oct 8. J Biol Chem. 2008. PMID: 18842589 Free PMC article.

6

Structure of a multidrug transporter.

Gottesman MM, Ambudkar SV, Xia D. Gottesman MM, et al. Among authors: xia d. Nat Biotechnol. 2009 Jun;27(6):546-7. doi: 10.1038/nbt0609-546. Nat Biotechnol. 2009. PMID: 19513059 Free PMC article. No abstract available.

7

The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Ananthaswamy N, Rutledge R, Sauna ZE, Ambudkar SV, Dine E, Nelson E, Xia D, Golin J. Ananthaswamy N, et al. Among authors: xia d. Biochemistry. 2010 Jun 1;49(21):4440-9. doi: 10.1021/bi100394j. Biochemistry. 2010. PMID: 20426485 Free PMC article.

8

Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance.

Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM. Shen DW, et al. Among authors: xia d. J Cell Physiol. 2010 Nov;225(3):822-8. doi: 10.1002/jcp.22287. J Cell Physiol. 2010. PMID: 20589834 Free PMC article.

9

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

Pluchino KM, Hall MD, Moen JK, Chufan EE, Fetsch PA, Shukla S, Gill DR, Hyde SC, Xia D, Ambudkar SV, Gottesman MM. Pluchino KM, et al. Among authors: xia d. Biochemistry. 2016 Feb 23;55(7):1010-23. doi: 10.1021/acs.biochem.5b01064. Epub 2016 Feb 10. Biochemistry. 2016. PMID: 26820614 Free PMC article.

10

Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.

Frank GA, Shukla S, Rao P, Borgnia MJ, Bartesaghi A, Merk A, Mobin A, Esser L, Earl LA, Gottesman MM, Xia D, Ambudkar SV, Subramaniam S. Frank GA, et al. Among authors: xia d. Mol Pharmacol. 2016 Jul;90(1):35-41. doi: 10.1124/mol.116.104190. Epub 2016 May 11. Mol Pharmacol. 2016. PMID: 27190212 Free PMC article.

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