Xing L - Search Results

1

Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors.

Wei M, Peng X, Xing L, Dai Y, Huang R, Geng M, Zhang A, Ai J, Song Z. Wei M, et al. Among authors: xing l. Eur J Med Chem. 2018 Jun 25;154:9-28. doi: 10.1016/j.ejmech.2018.05.005. Epub 2018 May 16. Eur J Med Chem. 2018. PMID: 29775937

2

Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: design, synthesis, and structure-activity relationship study.

Jiang X, Zhou J, Ai J, Song Z, Peng X, Xing L, Xi Y, Guo J, Yao Q, Ding J, Geng M, Zhang A. Jiang X, et al. Among authors: xing l. Eur J Med Chem. 2015 Nov 13;105:39-56. doi: 10.1016/j.ejmech.2015.10.005. Epub 2015 Oct 9. Eur J Med Chem. 2015. PMID: 26476749

3

An orally available tyrosine kinase ALK and RET dual inhibitor bearing the tetracyclic benzo[b]carbazolone core.

Song Z, Xia Z, Ji Y, Xing L, Gao Y, Ai J, Geng M, Zhang A. Song Z, et al. Among authors: xing l. Eur J Med Chem. 2016 Aug 8;118:244-9. doi: 10.1016/j.ejmech.2016.04.046. Epub 2016 Apr 19. Eur J Med Chem. 2016. PMID: 27131066

4

Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core.

Han M, Wang C, Ji Y, Song Z, Xing L, Su Y, Wang X, Zhang A, Ai J, Geng M. Han M, et al. Among authors: xing l. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5399-5402. doi: 10.1016/j.bmcl.2016.10.039. Epub 2016 Oct 14. Bioorg Med Chem Lett. 2016. PMID: 27769623

5

Synthesis and structure-activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors.

Wang C, Liu H, Song Z, Ji Y, Xing L, Peng X, Wang X, Ai J, Geng M, Zhang A. Wang C, et al. Among authors: xing l. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2544-2548. doi: 10.1016/j.bmcl.2017.03.088. Epub 2017 Mar 31. Bioorg Med Chem Lett. 2017. PMID: 28404375

6

Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core.

Wang Y, Xing L, Ji Y, Ye J, Dai Y, Gu W, Ai J, Song Z. Wang Y, et al. Among authors: xing l. Bioorg Med Chem Lett. 2019 Mar 15;29(6):836-838. doi: 10.1016/j.bmcl.2019.01.018. Epub 2019 Jan 21. Bioorg Med Chem Lett. 2019. PMID: 30685094

7

Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage.

Song Z, Liu B, Peng X, Gu W, Sun Y, Xing L, Xu Y, Geng M, Ai J, Zhang A. Song Z, et al. Among authors: xing l. J Med Chem. 2021 Nov 25;64(22):16687-16702. doi: 10.1021/acs.jmedchem.1c01422. Epub 2021 Nov 11. J Med Chem. 2021. PMID: 34761679 Free article.

8

Corrigendum to "Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core" [Bioorg. Med. Chem. Lett. 26 (2016) 5399-5402].

Han M, Wang C, Ji Y, Song Z, Xing L, Su Y, Wang X, Zhang A, Ai J, Geng M. Han M, et al. Among authors: xing l. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126931. doi: 10.1016/j.bmcl.2019.126931. Epub 2020 Jan 2. Bioorg Med Chem Lett. 2020. PMID: 31902709 No abstract available.

9

Palladium-catalyzed double C-H activation: one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones from 5-pyrazolones and aryl iodides.

Fan Z, Wu K, Xing L, Yao Q, Zhang A. Fan Z, et al. Among authors: xing l. Chem Commun (Camb). 2014 Feb 18;50(14):1682-4. doi: 10.1039/c3cc47989g. Epub 2014 Jan 6. Chem Commun (Camb). 2014. PMID: 24394189

10

Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.

Fensome A, Ambler CM, Arnold E, Banker ME, Clark JD, Dowty ME, Efremov IV, Flick A, Gerstenberger BS, Gifford RS, Gopalsamy A, Hegen M, Jussif J, Limburg DC, Lin TH, Pierce BS, Sharma R, Trujillo JI, Vajdos FF, Vincent F, Wan ZK, Xing L, Yang X, Yang X. Fensome A, et al. Among authors: xing l. Bioorg Med Chem. 2020 May 15;28(10):115481. doi: 10.1016/j.bmc.2020.115481. Epub 2020 Mar 31. Bioorg Med Chem. 2020. PMID: 32253095

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