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1,040 results

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Page 1
Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles.
Ratnayaka-Gamage ND, Alesi LR, Zerafa N, Stringer JM, Hutt KJ. Ratnayaka-Gamage ND, et al. Front Endocrinol (Lausanne). 2023 Oct 10;14:1268009. doi: 10.3389/fendo.2023.1268009. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37900135 Free PMC article.
METHODS: To investigate the importance of KU80 following endogenous and exogenous DNA damage, ovaries from conditional oocyte-specific Xrcc5 knockout (Xrcc5 cKO) and wildtype (WT) mice that were aged or exposed to DNA damage-inducing chemotherapy were compared. ...R …
METHODS: To investigate the importance of KU80 following endogenous and exogenous DNA damage, ovaries from conditional oocyte-specific Xr …
XRCC5 downregulated by TRIM25 is susceptible for lens epithelial cell apoptosis.
Mao X, Ji M, Kang L, Qin B, Luo J, Zhang W, Wu A, Yuan Y, Zhang G, Guan H. Mao X, et al. Cell Signal. 2022 Jun;94:110314. doi: 10.1016/j.cellsig.2022.110314. Epub 2022 Mar 22. Cell Signal. 2022. PMID: 35331835
TRIM25 interacted with XRCC5 and ubiquitinated it for degradation. Further studies showed that XRCC5 overexpression notably repressed UVB-induced apoptosis, while XRCC5 knockdown promoted apoptosis. ...In conclusion, TRIM25 mediates ubiquitination of XRCC5 …
TRIM25 interacted with XRCC5 and ubiquitinated it for degradation. Further studies showed that XRCC5 overexpression notably re …
Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis.
Zhou LP, Luan H, Dong XH, Jin GJ, Man DL, Shang H. Zhou LP, et al. Asian Pac J Cancer Prev. 2012;13(8):3637-43. doi: 10.7314/apjcp.2012.13.8.3637. Asian Pac J Cancer Prev. 2012. PMID: 23098447 Free article. Review.
OBJECTIVE: Non-homologous end joining (NHEJ) is a pathway for repairing DNA double-strand breaks. Recent publications indicated that XRCC5, XRCC6 and XRCC7 genes may participate in the pathogenesis of breast cancer. The aim of this Human Genome Epidemiology (HuGE) review a …
OBJECTIVE: Non-homologous end joining (NHEJ) is a pathway for repairing DNA double-strand breaks. Recent publications indicated that XRCC …
XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study.
Yu LX, Liu LY, Xiang YJ, Wang F, Zhou F, Huang SY, Zheng C, Ye CM, Zhou WZ, Yin GS, Zhang JL, Cui SD, Tian FG, Fan ZM, Geng CZ, Cao XC, Yang ZL, Wang X, Liang H, Wang S, Jiang HC, Duan XN, Wang HB, Li GL, Wang QT, Zhang JG, Jin F, Tang JH, Li L, Zhu SG, Zuo WS, Ma ZB, Yu ZG. Yu LX, et al. Cancer Med. 2021 Apr;10(8):2752-2762. doi: 10.1002/cam4.3847. Epub 2021 Mar 18. Cancer Med. 2021. PMID: 33734613 Free PMC article.
This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. ...Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary acc …
This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smo …
Role of the XRCC5/XRCC6 dimer in carcinogenesis and pharmacogenomics.
Bau DT, Tsai CW, Wu CN. Bau DT, et al. Pharmacogenomics. 2011 Apr;12(4):515-34. doi: 10.2217/pgs.10.209. Pharmacogenomics. 2011. PMID: 21521024 Review.
In this article, we have summarized the studies investigating the association between the XRCC5/XRCC6 dimer and the susceptibility to multiple cancers and discuss its role in carcinogenesis and its potential application to anticancer drug discovery....
In this article, we have summarized the studies investigating the association between the XRCC5/XRCC6 dimer and the susceptibility to …
Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma.
Lee IN, Yang JT, Huang C, Huang HC, Wu YP, Chen JC. Lee IN, et al. Oncol Lett. 2021 Jun;21(6):443. doi: 10.3892/ol.2021.12704. Epub 2021 Apr 6. Oncol Lett. 2021. PMID: 33868481 Free PMC article.
In addition, XRCC5 knockdown could significantly increase TMZ sensitivity in GBM cells, while XRCC5 overexpression caused the cancer cells to be resistant to TMZ. Both the in vivo and in vitro experiments showed that TMZ treatment could induce expression of XRCC5 …
In addition, XRCC5 knockdown could significantly increase TMZ sensitivity in GBM cells, while XRCC5 overexpression caused the …
XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers.
Zhang Z, Zheng F, Yu Z, Hao J, Chen M, Yu W, Guo W, Chen Y, Huang W, Duan Z, Deng W. Zhang Z, et al. PLoS One. 2017 Oct 19;12(10):e0186900. doi: 10.1371/journal.pone.0186900. eCollection 2017. PLoS One. 2017. PMID: 29049411 Free PMC article.
Moreover, the role of p300 (a transcription co-activator) in acetylating XRCC5 to co-regulate COX-2 expression was also evaluated. Immunofluorescence assay and confocal microscopy showed that XRCC5 and p300 proteins were co-located in the nucleus of colon cancer cel …
Moreover, the role of p300 (a transcription co-activator) in acetylating XRCC5 to co-regulate COX-2 expression was also evaluated. Im …
The NRF2-dependent transcriptional axis, XRCC5/hTERT drives tumor progression and 5-Fu insensitivity in hepatocellular carcinoma.
Liu T, Long Q, Li L, Gan H, Hu X, Long H, Yang L, Pang P, Wang S, Deng W. Liu T, et al. Mol Ther Oncolytics. 2021 Dec 21;24:249-261. doi: 10.1016/j.omto.2021.12.012. eCollection 2022 Mar 17. Mol Ther Oncolytics. 2021. PMID: 35071747 Free PMC article.
Functionally, the transgenic expression of XRCC5 promoted HCC progression and 5-fluorouracil resistance, whereas short hairpin RNA knockdown of XRCC5 had converse effects in vitro and in vivo. ...However, the upregulation was insignificant when NRF2 was reduced, sug …
Functionally, the transgenic expression of XRCC5 promoted HCC progression and 5-fluorouracil resistance, whereas short hairpin RNA kn …
Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes.
Cai X, Stringer JM, Zerafa N, Carroll J, Hutt KJ. Cai X, et al. Cell Death Dis. 2023 Jul 5;14(7):397. doi: 10.1038/s41419-023-05886-x. Cell Death Dis. 2023. PMID: 37407587 Free PMC article.
When higher levels of DNA damage were induced, a severe delay in M-phase entry was observed in oocytes lacking XRCC5 compared to wild-type oocytes, suggesting that Ku80-dependent repair of DNA damage is important for the timely release of oocytes from prophase I and resump …
When higher levels of DNA damage were induced, a severe delay in M-phase entry was observed in oocytes lacking XRCC5 compared to wild …
1,040 results