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Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication.
Wang Y, Wang W, Xu L, Zhou X, Shokrollahi E, Felczak K, van der Laan LJ, Pankiewicz KW, Sprengers D, Raat NJ, Metselaar HJ, Peppelenbosch MP, Pan Q. Wang Y, et al. Among authors: xu l. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2834-48. doi: 10.1128/AAC.02700-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26926637 Free PMC article.
Modeling rotavirus infection and antiviral therapy using primary intestinal organoids.
Yin Y, Bijvelds M, Dang W, Xu L, van der Eijk AA, Knipping K, Tuysuz N, Dekkers JF, Wang Y, de Jonge J, Sprengers D, van der Laan LJ, Beekman JM, Ten Berge D, Metselaar HJ, de Jonge H, Koopmans MP, Peppelenbosch MP, Pan Q. Yin Y, et al. Among authors: xu l. Antiviral Res. 2015 Nov;123:120-31. doi: 10.1016/j.antiviral.2015.09.010. Epub 2015 Sep 25. Antiviral Res. 2015. PMID: 26408355
IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN-stimulated genes.
Xu L, Zhou X, Wang W, Wang Y, Yin Y, Laan LJ, Sprengers D, Metselaar HJ, Peppelenbosch MP, Pan Q. Xu L, et al. FASEB J. 2016 Oct;30(10):3352-3367. doi: 10.1096/fj.201600356R. Epub 2016 Jun 21. FASEB J. 2016. PMID: 27328944
We demonstrated that IRF1 effectively inhibits HEV replication through the activation of the JAK-STAT pathway, and the subsequent transcription of antiviral ISGs, but independent of IFN production.-Xu, L., Zhou, X., Wang, W., Wang, Y., Yin, Y., van der Laan, L
We demonstrated that IRF1 effectively inhibits HEV replication through the activation of the JAK-STAT pathway, and the subsequent transcript …
Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development.
Yin Y, Wang Y, Dang W, Xu L, Su J, Zhou X, Wang W, Felczak K, van der Laan LJ, Pankiewicz KW, van der Eijk AA, Bijvelds M, Sprengers D, de Jonge H, Koopmans MP, Metselaar HJ, Peppelenbosch MP, Pan Q. Yin Y, et al. Among authors: xu l. Antiviral Res. 2016 Sep;133:41-9. doi: 10.1016/j.antiviral.2016.07.017. Epub 2016 Jul 25. Antiviral Res. 2016. PMID: 27468950
Hepatitis E Virus Infects Neurons and Brains.
Zhou X, Huang F, Xu L, Lin Z, de Vrij FMS, Ayo-Martin AC, van der Kroeg M, Zhao M, Yin Y, Wang W, Cao W, Wang Y, Kushner SA, Marie Peron J, Alric L, de Man RA, Jacobs BC, van Eijk JJ, Aronica EMA, Sprengers D, Metselaar HJ, de Zeeuw CI, Dalton HR, Kamar N, Peppelenbosch MP, Pan Q. Zhou X, et al. Among authors: xu l. J Infect Dis. 2017 Apr 15;215(8):1197-1206. doi: 10.1093/infdis/jix079. J Infect Dis. 2017. PMID: 28199701
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