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Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.
Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ. Chang J, et al. Among authors: xu l. Nat Med. 2017 Apr;23(4):450-460. doi: 10.1038/nm.4309. Epub 2017 Mar 13. Nat Med. 2017. PMID: 28288111 Free PMC article.
Acidosis reduces neuronal apoptosis.
Xu L, Glassford AJ, Giaccia AJ, Giffard RG. Xu L, et al. Neuroreport. 1998 Mar 30;9(5):875-9. doi: 10.1097/00001756-199803300-00021. Neuroreport. 1998. PMID: 9579683
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