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CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis.
Leung GK, Ying D, Mak CC, Chen XY, Xu W, Yeung KS, Wong WL, Chu YW, Mok GT, Chau CS, McLuskey J, Ong WP, Leong HY, Chan KY, Yang W, Chen JH, Li AM, Sham PC, Lau YL, Chung BH, Lee SL. Leung GK, et al. Among authors: xu w. Mol Genet Genomic Med. 2016 Nov 13;5(1):40-49. doi: 10.1002/mgg3.258. eCollection 2017 Jan. Mol Genet Genomic Med. 2016. PMID: 28116329 Free PMC article.
A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis-causing mutation.
Chen X, Zhu S, Zhenin M, Xu W, Bose SJ, Wong MP, Leung GPH, Senderowitz H, Chen JH. Chen X, et al. Among authors: xu w. FASEB J. 2019 Apr;33(4):5126-5142. doi: 10.1096/fj.201801218RR. Epub 2019 Jan 22. FASEB J. 2019. PMID: 30668920
Importantly, correcting defects from G509 displacement in deltaF508-CFTR may offer a new avenue for drug discovery and CF treatments.-Chen, X., Zhu, S., Zhenin, M., Xu, W., Bose, S. J., Wong, M. P.-F., Leung, G. P. H., Senderowitz, H., Chen, J....
Importantly, correcting defects from G509 displacement in deltaF508-CFTR may offer a new avenue for drug discovery and CF treatments.-Chen, …
Development and Standardization of an Osteoradionecrosis Classification System in Head and Neck Cancer: Implementation of a Risk-Based Model.
Watson E EE, Hueniken K, Lee J, Huang SH, El Maghrabi A, Xu W, Moreno AC, Tsai CJ, Hahn E, McPartlin AJ, Yao CMKL, Goldstein DP, De Almeida JR, Waldon JN, Fuller CD, Hope AJ, Ruggiero SL, Glogauer M, Hosni AA. Watson E EE, et al. Among authors: xu w. J Clin Oncol. 2024 May 1:JCO2301951. doi: 10.1200/JCO.23.01951. Online ahead of print. J Clin Oncol. 2024. PMID: 38691822
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