A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis-causing mutation.
Chen X, Zhu S, Zhenin M, Xu W, Bose SJ, Wong MP, Leung GPH, Senderowitz H, Chen JH.
Chen X, et al. Among authors: xu w.
FASEB J. 2019 Apr;33(4):5126-5142. doi: 10.1096/fj.201801218RR. Epub 2019 Jan 22.
FASEB J. 2019.
PMID: 30668920
Importantly, correcting defects from G509 displacement in deltaF508-CFTR may offer a new avenue for drug discovery and CF treatments.-Chen, X., Zhu, S., Zhenin, M., Xu, W., Bose, S. J., Wong, M. P.-F., Leung, G. P. H., Senderowitz, H., Chen, J....
Importantly, correcting defects from G509 displacement in deltaF508-CFTR may offer a new avenue for drug discovery and CF treatments.-Chen, …