Enhanced mTOR complex 1 signaling attenuates diabetic cardiac injury in OVE26 mice.
Xu X, Kobayashi S, Timm D, Huang Y, Zhao F, Shou W, Liang Q.
Xu X, et al.
FASEB J. 2019 Nov;33(11):12800-12811. doi: 10.1096/fj.201901206R. Epub 2019 Aug 30.
FASEB J. 2019.
PMID: 31469601
These findings demonstrated that the enhanced mTORC1 signaling in the OVE26 diabetic heart was an adaptive response that limited cardiac dysfunction, suggesting that manipulations that enhance mTORC1 activity may reduce diabetic cardiac injury, in sharp contrast to the results pr …
These findings demonstrated that the enhanced mTORC1 signaling in the OVE26 diabetic heart was an adaptive response that limited cardiac dys …