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The sigma receptor ligand N-phenylpropyl-N'-(4-methoxyphenethyl)3piperazine (YZ-067) enhances the cocaine conditioned-rewarding properties while inhibiting the development of sensitization of cocaine in mice.
Tapia MA, Sage AS, Fullerton EI, Judd JM, Hildebrant PC, Will MJ, Lever SZ, Lever JR, Miller DK. Tapia MA, et al. Psychopharmacology (Berl). 2020 Mar;237(3):723-734. doi: 10.1007/s00213-019-05411-z. Epub 2019 Dec 10. Psychopharmacology (Berl). 2020. PMID: 31822924
RESULTS: YZ-067 (10 or 31.6 mumol/kg) did not have intrinsic effects on place preference or place aversion. Interestingly, the 31.6 mumol/kg YZ-067 dose enhanced the development of cocaine place preference, while 10 mumol/kg YZ-067 attenu …
RESULTS: YZ-067 (10 or 31.6 mumol/kg) did not have intrinsic effects on place preference or place aversion. Interestingly, the …
N-phenylpropyl-N'-substituted piperazines occupy sigma receptors and alter methamphetamine-induced hyperactivity in mice.
Miller DK, Park ES, Lever SZ, Lever JR. Miller DK, et al. Pharmacol Biochem Behav. 2016 Nov-Dec;150-151:198-206. doi: 10.1016/j.pbb.2016.11.003. Epub 2016 Nov 13. Pharmacol Biochem Behav. 2016. PMID: 27851908 Free PMC article.
This study examined the effect of the N-phenylpropyl-N'-substituted piperazine ligands SA4503 (3.4-dimethoxyphenethyl), YZ-067 (4-methoxyphenethyl), YZ-185 (3-methoxyphenethyl) and Nahas-3h (4-methoxybenzyl) on methamphetamine-induced hyperactivity in mice. ...At th …
This study examined the effect of the N-phenylpropyl-N'-substituted piperazine ligands SA4503 (3.4-dimethoxyphenethyl), YZ-067 …
Effects of N-phenylpropyl-N'-substituted piperazine sigma receptor ligands on cocaine-induced hyperactivity in mice.
Sage AS, Oelrichs CE, Davis DC, Fan KH, Nahas RI, Lever SZ, Lever JR, Miller DK. Sage AS, et al. Pharmacol Biochem Behav. 2013 Sep;110:201-7. doi: 10.1016/j.pbb.2013.07.006. Epub 2013 Jul 24. Pharmacol Biochem Behav. 2013. PMID: 23891829
YZ-067 and YZ-185 are known to attenuate cocaine-induced convulsions, while Nahas-3h has not been tested in behavioral studies. Nahas-3h significantly attenuated cocaine-induced hyperactivity. YZ-067 decreased the effect of cocaine in a dose-dependent …
YZ-067 and YZ-185 are known to attenuate cocaine-induced convulsions, while Nahas-3h has not been tested in behavioral studies …