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4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T. Al Rahim M, et al. Among authors: yamakoshi h. Biochemistry. 2009 Aug 18;48(32):7713-21. doi: 10.1021/bi901088w. Biochemistry. 2009. PMID: 19601643
High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound.
Saigusa D, Shibuya M, Jinno D, Yamakoshi H, Iwabuchi Y, Yokosuka A, Mimaki Y, Naganuma A, Ohizumi Y, Tomioka Y, Yamakuni T. Saigusa D, et al. Among authors: yamakoshi h. Anal Bioanal Chem. 2011 Jul;400(10):3635-41. doi: 10.1007/s00216-011-5031-2. Epub 2011 May 11. Anal Bioanal Chem. 2011. PMID: 21559759
48 results