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Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. J Med Chem. 2011 Apr 14;54(7):2029-38. doi: 10.1021/jm101023r. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366266 Free PMC article.
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. J Med Chem. 2010 Aug 12;53(15):5491-501. doi: 10.1021/jm100157m. J Med Chem. 2010. PMID: 20617791 Free PMC article.
Functional selectivity in cannabinoid signaling.
Varga EV, Georgieva T, Tumati S, Alves I, Salamon Z, Tollin G, Yamamura HI, Roeske WR. Varga EV, et al. Among authors: yamamura hi. Curr Mol Pharmacol. 2008 Nov;1(3):273-84. doi: 10.2174/1874467210801030273. Curr Mol Pharmacol. 2008. PMID: 20021440 Review.
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. Bioorg Med Chem. 2009 Oct 15;17(20):7337-43. doi: 10.1016/j.bmc.2009.08.035. Epub 2009 Aug 21. Bioorg Med Chem. 2009. PMID: 19762245 Free PMC article.
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Nair P, et al. Among authors: yamamura hi. Adv Exp Med Biol. 2009;611:537-8. doi: 10.1007/978-0-387-73657-0_235. Adv Exp Med Biol. 2009. PMID: 19400302 Free PMC article. No abstract available.
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
Fioravanti B, De Felice M, Stucky CL, Medler KA, Luo MC, Gardell LR, Ibrahim M, Malan TP Jr, Yamamura HI, Ossipov MH, King T, Lai J, Porreca F, Vanderah TW. Fioravanti B, et al. Among authors: yamamura hi. J Neurosci. 2008 Nov 5;28(45):11593-602. doi: 10.1523/JNEUROSCI.3322-08.2008. J Neurosci. 2008. PMID: 18987195 Free PMC article.
500 results