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Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE. Chen F, et al. Among authors: yang a, yang ds. J Biol Chem. 2000 Nov 24;275(47):36794-802. doi: 10.1074/jbc.M006986200. J Biol Chem. 2000. PMID: 10962005 Free article.
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Yang DS, et al. Among authors: yang aj. Brain. 2011 Jan;134(Pt 1):258-77. doi: 10.1093/brain/awq341. Brain. 2011. PMID: 21186265 Free PMC article.
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Yang DS, et al. Among authors: yang aj. Autophagy. 2011 Jul;7(7):788-9. doi: 10.4161/auto.7.7.15596. Epub 2011 Jul 1. Autophagy. 2011. PMID: 21464620 Free PMC article.
5,279 results