Yang H - Search Results

1

Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt.

Kim YB, Kang CW, Ranatunga S, Yang H, Sebti SM, Del Valle JR. Kim YB, et al. Among authors: yang h. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4650-4653. doi: 10.1016/j.bmcl.2014.08.040. Epub 2014 Aug 28. Bioorg Med Chem Lett. 2014. PMID: 25205195 Free PMC article.

2

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

Lawrence HR, Martin MP, Luo Y, Pireddu R, Yang H, Gevariya H, Ozcan S, Zhu JY, Kendig R, Rodriguez M, Elias R, Cheng JQ, Sebti SM, Schonbrunn E, Lawrence NJ. Lawrence HR, et al. Among authors: yang h. J Med Chem. 2012 Sep 13;55(17):7392-7416. doi: 10.1021/jm300334d. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22803810 Free PMC article.

3

The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.

Yang H, Xiang S, Kazi A, Sebti SM. Yang H, et al. J Biol Chem. 2020 Mar 6;295(10):3055-3063. doi: 10.1074/jbc.RA119.011930. Epub 2020 Jan 30. J Biol Chem. 2020. PMID: 32001619 Free PMC article.

4

Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.

Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence HR, Beato F, Kang Y, Kim MP, Delitto A, Underwood PW, Fleming JB, Trevino JG, Hamilton AD, Sebti SM. Kazi A, et al. Among authors: yang h. Clin Cancer Res. 2019 Oct 1;25(19):5984-5996. doi: 10.1158/1078-0432.CCR-18-3399. Epub 2019 Jun 21. Clin Cancer Res. 2019. PMID: 31227505 Free PMC article.

5

Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.

Berndt N, Patel R, Yang H, Balasis ME, Sebti SM. Berndt N, et al. Among authors: yang h. Cell Cycle. 2013 Jul 1;12(13):2024-32. doi: 10.4161/cc.25043. Epub 2013 Jun 6. Cell Cycle. 2013. PMID: 23777806 Free PMC article.

6

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.

Yang H, Lawrence HR, Kazi A, Gevariya H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence NJ, Sebti SM. Yang H, et al. Oncotarget. 2014 May 30;5(10):2947-61. doi: 10.18632/oncotarget.1615. Oncotarget. 2014. PMID: 24930769 Free PMC article.

7

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors.

Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM. Kazi A, et al. Among authors: yang h. Nat Commun. 2018 Dec 4;9(1):5154. doi: 10.1038/s41467-018-07644-6. Nat Commun. 2018. PMID: 30514931 Free PMC article.

8

A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation.

Zhang X, Sun Y, Pireddu R, Yang H, Urlam MK, Lawrence HR, Guida WC, Lawrence NJ, Sebti SM. Zhang X, et al. Among authors: yang h. Cancer Res. 2013 Mar 15;73(6):1922-33. doi: 10.1158/0008-5472.CAN-12-3175. Epub 2013 Jan 15. Cancer Res. 2013. PMID: 23322008 Free PMC article.

9

Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.

Kazi A, Chen L, Xiang S, Vangipurapu R, Yang H, Beato F, Fang B, Williams TM, Husain K, Underwood P, Fleming JB, Malafa M, Welsh EA, Koomen J, Trevino J, Sebti SM. Kazi A, et al. Among authors: yang h. Clin Cancer Res. 2021 Jul 15;27(14):4012-4024. doi: 10.1158/1078-0432.CCR-20-4781. Epub 2021 Apr 20. Clin Cancer Res. 2021. PMID: 33879459 Free PMC article.

10

Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function.

Betts BC, Veerapathran A, Pidala J, Yang H, Horna P, Walton K, Cubitt CL, Gunawan S, Lawrence HR, Lawrence NJ, Sebti SM, Anasetti C. Betts BC, et al. Among authors: yang h. Sci Transl Med. 2017 Jan 11;9(372):eaai8269. doi: 10.1126/scitranslmed.aai8269. Sci Transl Med. 2017. PMID: 28077684 Free PMC article.

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