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An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
Avar M, Heinzer D, Thackray AM, Liu Y, Hruska-Plochan M, Sellitto S, Schaper E, Pease DP, Yin JA, Lakkaraju AK, Emmenegger M, Losa M, Chincisan A, Hornemann S, Polymenidou M, Bujdoso R, Aguzzi A. Avar M, et al. Among authors: yin ja. EMBO J. 2022 Dec 1;41(23):e112338. doi: 10.15252/embj.2022112338. Epub 2022 Oct 18. EMBO J. 2022. PMID: 36254605 Free PMC article.
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference.
Heinzer D, Avar M, Pease DP, Dhingra A, Yin JA, Schaper E, Doğançay B, Emmenegger M, Spinelli A, Maggi K, Chincisan A, Mead S, Hornemann S, Heutink P, Aguzzi A. Heinzer D, et al. Among authors: yin ja. PLoS Pathog. 2021 Oct 27;17(10):e1010013. doi: 10.1371/journal.ppat.1010013. eCollection 2021 Oct. PLoS Pathog. 2021. PMID: 34705895 Free PMC article.
105 results