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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Diseases and Injuries Collaborators. GBD 2021 Diseases and Injuries Collaborators. Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print. Lancet. 2024. PMID: 38642570 Free article.
Crystal structure and Hirshfeld surface analysis of (E)-2-[2-(2-amino-1-cyano-2-oxo-ethyl-idene)hydrazin-1-yl]benzoic acid N,N-di-methylformamide monosolvate.
Hajiyeva SR, Huseynov FE, Atioğlu Z, Akkurt M, Bhattarai A. Hajiyeva SR, et al. Acta Crystallogr E Crystallogr Commun. 2024 Jan 5;80(Pt 2):110-116. doi: 10.1107/S2056989023011118. eCollection 2024 Feb 1. Acta Crystallogr E Crystallogr Commun. 2024. PMID: 38333118 Free PMC article.
Mol-ecules A and B both feature intra-molecular N-HO hydrogen bonds, forming S(6) ring motifs and consolidating the mol-ecular configuration. ...
Mol-ecules A and B both feature intra-molecular N-HO hydrogen bonds, forming S(6) ring motifs and consolidating the mol-ecular config …
Trapping an unprecedented octacoordinated iron(II) complex with neutral bis-tetrazolylpyridyl ligands and solvent molecules.
Rigamonti L, Marchi L, Fiorini V, Stagni S, Zacchini S, Pinkowicz D, Dziedzic-Kocurek K, Forni A, Muniz Miranda F, Mazzoni R. Rigamonti L, et al. Dalton Trans. 2024 Feb 20;53(8):3490-3498. doi: 10.1039/d3dt04026g. Dalton Trans. 2024. PMID: 38270176
Metalation of the neutral tridentate nitrogen-donor mer-coordinating ligand 2,6-bis(2-(methyl)-2H-tetrazol-5-yl)pyridine (Me(2)btp) with Fe(ClO(4))(2).6H(2)O through accurate solvent polarity control enables the selective crystallization of [Fe(HS/LS)(Me(2)btp)(2)](ClO(4)) …
Metalation of the neutral tridentate nitrogen-donor mer-coordinating ligand 2,6-bis(2-(methyl)-2H-tetrazol-5-yl)pyridine (Me(2)btp) w …
Association of Mean Upper Cervical Spinal Cord Cross-Sectional Area With Cerebral Small Vessel Disease: A Community-Based Cohort Study.
Meng Y, Wang S, Zhu W, Wang T, Liu D, Wang M, Pi J, Liu Y, Zhuo Z, Pan Y, Wang Y. Meng Y, et al. Stroke. 2024 Mar;55(3):687-695. doi: 10.1161/STROKEAHA.123.044666. Epub 2024 Jan 25. Stroke. 2024. PMID: 38269540
The Spinal Cord Toolbox was used to measure the upper cervical spinal cord cross-sectional area of the C1 to C3 segments of the spinal cord and its average value was taken as MUCCA. ...
The Spinal Cord Toolbox was used to measure the upper cervical spinal cord cross-sectional area of the C1 to C3 segments of the spina …
Single-Cell Transcriptomics Reveals Crucial Cell Subsets and Functional Heterogeneity Associated With Carotid Atherosclerosis and Cerebrovascular Events.
Tan J, Liang Y, Yang Z, He Q, Tong J, Deng Y, Guo W, Liang K, Tang J, Shi W, Yu B. Tan J, et al. Arterioscler Thromb Vasc Biol. 2023 Dec;43(12):2312-2332. doi: 10.1161/ATVBAHA.123.318974. Epub 2023 Oct 26. Arterioscler Thromb Vasc Biol. 2023. PMID: 37881939 Free PMC article.
Two plaque-specific monocyte subsets performed diametrically opposed functions, EREG(+) monocytes promoted cerebrovascular events while C3(+) monocytes are anti-inflammatory. Similarly, IGF1(+) and HS3ST2(+) macrophages with classical proinflammatory M1 macrophage features …
Two plaque-specific monocyte subsets performed diametrically opposed functions, EREG(+) monocytes promoted cerebrovascular events while C …
Isolation of Hydrazide-alkenes with Different Amino Acid Origins from an Azoxy-alkene-Producing Mutant of Streptomyces rochei 7434AN4.
Tanaka Y, Nagano H, Okano M, Kishimoto T, Tatsukawa A, Kunitake H, Fukumoto A, Anzai Y, Arakawa K. Tanaka Y, et al. J Nat Prod. 2023 Sep 22;86(9):2185-2192. doi: 10.1021/acs.jnatprod.3c00476. Epub 2023 Aug 25. J Nat Prod. 2023. PMID: 37624992
KA57D1 has a molecular formula of C(12)H(22)N(2)O(2), and NMR analysis revealed KA57D1 is a novel hydrazide-alkene compound, (Z)-N-acetyl-N'-(hex-1-en-1-yl)isobutylhydrazide. Labeling studies indicated that nitrogen Nbeta of KA57D1 is derived from l-glutamic acid, and the …
KA57D1 has a molecular formula of C(12)H(22)N(2)O(2), and NMR analysis revealed KA57D1 is a novel hydrazide-alkene compound, (Z)-N-acetyl-N' …
CuII Pyrazolyl-Benzimidazole Dinuclear Complexes with Remarkable Antioxidant Activity.
Chkirate K, Ati GA, Karrouchi K, Fettach S, Chakchak H, Mague JT, Radi S, Adarsh NN, Abbes Faouzi ME, Essassi EM, Garcia Y. Chkirate K, et al. Chembiochem. 2023 Oct 17;24(20):e202300331. doi: 10.1002/cbic.202300331. Epub 2023 Aug 29. Chembiochem. 2023. PMID: 37548339
Three dinuclear coordination complexes generated from 1-n-butyl-2-((5-methyl-1H-pyrazole-3-yl)methyl)-1H-benzimidazole (L), have been synthesized and characterized spectroscopically and structurally by single crystal X-ray diffraction analysis. ...
Three dinuclear coordination complexes generated from 1-n-butyl-2-((5-methyl-1H-pyrazole-3-yl)methyl)-1H-benzimidazole (L), have been …
Structural and mechanistic insights into the MCM8/9 helicase complex.
Weng Z, Zheng J, Zhou Y, Lu Z, Wu Y, Xu D, Li H, Liang H, Liu Y. Weng Z, et al. Elife. 2023 Aug 3;12:RP87468. doi: 10.7554/eLife.87468. Elife. 2023. PMID: 37535404 Free PMC article.
Multiple characteristic hairpins from the N-terminal oligosaccharide/oligonucleotide (OB) domains of MCM8/9 protrude into the central channel and serve to unwind the duplex DNA. When activated by HROB, the structure of MCM8/9's N-tier ring converts its symmetry from C3 …
Multiple characteristic hairpins from the N-terminal oligosaccharide/oligonucleotide (OB) domains of MCM8/9 protrude into the central channe …
3-Indolepropionic acid mitigates sub-acute toxicity in the cardiomyocytes of epirubicin-treated female rats.
Owumi S, Arunsi U, Otunla M, Adebisi G, Altayyar A, Irozuru C. Owumi S, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):507-520. doi: 10.1007/s00210-023-02618-y. Epub 2023 Jul 21. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37477660
Endogenously derived 3-indolepropionic acid (3-IPA) from tryptophan metabolism is of interest due to its antioxidant capabilities which may have cardioprotective effects. Supplementation with 3-IPA may abate EPI's cardiotoxicity, and herein we studied the possibility of le …
Endogenously derived 3-indolepropionic acid (3-IPA) from tryptophan metabolism is of interest due to its antioxidant capabilities which may …
Pentaketides and 5-p-Hydroxyphenyl-2-pyridone Derivative from the Culture Extract of a Marine Sponge-Associated Fungus Hamigera avellanea KUFA0732.
Klaram R, Dethoup T, Machado FP, Gales L, Kumla D, Hafez Ghoran S, Sousa E, Mistry S, Silva AMS, Kijjoa A. Klaram R, et al. Mar Drugs. 2023 Jun 2;21(6):344. doi: 10.3390/md21060344. Mar Drugs. 2023. PMID: 37367669 Free PMC article.
Five undescribed pentaketide derivatives, (R)-6,8-dihydroxy-4,5-dimethyl-3-methylidene-3,4-dihydro-1H-2-benzopyran-1-one (1), [(3S,4R)-3,8-dihydroxy-6-methoxy-4,5-dimethyl-1-oxo-3,4-dihydro-1H-isochromen-3-yl]methyl acetate (2), (R)-5, 7-dimethoxy-3-((S)-(1-hydroxye …
Five undescribed pentaketide derivatives, (R)-6,8-dihydroxy-4,5-dimethyl-3-methylidene-3,4-dihydro-1H-2-benzopyran-1-one (1), [(3S,4R)-3,8-d …
553 results