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A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction.
Kinoshita K, Komatsu T, Nishide K, Hata Y, Hisajima N, Takahashi H, Kimoto K, Aonuma K, Tsushima E, Tabata T, Yoshida T, Mori H, Nishida K, Yamaguchi Y, Ichida F, Fukurotani K, Inoue H, Nishida N. Kinoshita K, et al. Among authors: yoshida t. J Mol Cell Cardiol. 2014 Jul;72:273-80. doi: 10.1016/j.yjmcc.2014.03.019. Epub 2014 Apr 5. J Mol Cell Cardiol. 2014. PMID: 24713462
Novel role of serine racemase in anti-apoptosis and metabolism.
Talukdar G, Inoue R, Yoshida T, Ishimoto T, Yaku K, Nakagawa T, Mori H. Talukdar G, et al. Among authors: yoshida t. Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3378-3387. doi: 10.1016/j.bbagen.2016.08.020. Epub 2016 Aug 30. Biochim Biophys Acta Gen Subj. 2017. PMID: 27585868
A novel serine racemase inhibitor suppresses neuronal over-activation in vivo.
Mori H, Wada R, Takahara S, Horino Y, Izumi H, Ishimoto T, Yoshida T, Mizuguchi M, Obita T, Gouda H, Hirono S, Toyooka N. Mori H, et al. Among authors: yoshida t. Bioorg Med Chem. 2017 Jul 15;25(14):3736-3745. doi: 10.1016/j.bmc.2017.05.011. Epub 2017 May 11. Bioorg Med Chem. 2017. PMID: 28533113
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase.
Takahara S, Nakagawa K, Uchiyama T, Yoshida T, Matsumoto K, Kawasumi Y, Mizuguchi M, Obita T, Watanabe Y, Hayakawa D, Gouda H, Mori H, Toyooka N. Takahara S, et al. Among authors: yoshida t. Bioorg Med Chem Lett. 2018 Feb 1;28(3):441-445. doi: 10.1016/j.bmcl.2017.12.021. Epub 2017 Dec 13. Bioorg Med Chem Lett. 2018. PMID: 29277459
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