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HIV-protease inhibitors block the enzymatic activity of purified Ste24p.
Hudon SE, Coffinier C, Michaelis S, Fong LG, Young SG, Hrycyna CA. Hudon SE, et al. Among authors: young sg. Biochem Biophys Res Commun. 2008 Sep 19;374(2):365-8. doi: 10.1016/j.bbrc.2008.07.033. Epub 2008 Jul 17. Biochem Biophys Res Commun. 2008. PMID: 18639527 Free PMC article.
Biochemical studies of Zmpste24-deficient mice.
Leung GK, Schmidt WK, Bergo MO, Gavino B, Wong DH, Tam A, Ashby MN, Michaelis S, Young SG. Leung GK, et al. Among authors: young sg. J Biol Chem. 2001 Aug 3;276(31):29051-8. doi: 10.1074/jbc.M102908200. Epub 2001 Jun 8. J Biol Chem. 2001. PMID: 11399759 Free article.
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, Van Bruggen N, Carano RA, Michaelis S, Griffey SM, Young SG. Bergo MO, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13049-54. doi: 10.1073/pnas.192460799. Epub 2002 Sep 16. Proc Natl Acad Sci U S A. 2002. PMID: 12235369 Free PMC article.
Prelamin A and lamin A appear to be dispensable in the nuclear lamina.
Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. Fong LG, et al. Among authors: young sr, young sg. J Clin Invest. 2006 Mar;116(3):743-52. doi: 10.1172/JCI27125. J Clin Invest. 2006. PMID: 16511604 Free PMC article.
Lamins A and C but not lamin B1 regulate nuclear mechanics.
Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. Lammerding J, et al. Among authors: young sg. J Biol Chem. 2006 Sep 1;281(35):25768-80. doi: 10.1074/jbc.M513511200. Epub 2006 Jul 5. J Biol Chem. 2006. PMID: 16825190 Free article.
451 results